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Effects of Oxytocin on Emotion Recognition and Response Inhibition

NCT ID: NCT02350946

Last Updated: 2015-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-31

Study Completion Date

2017-01-31

Brief Summary

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The purpose of this study is to shed light on the basic neurobiological mechanisms which underlie social information processing in healthy men. More specifically, we intend to examine whether a person's social competence level is related to the patterns of neural activity and his visual search strategies during evaluation of social scenes. Furthermore, it will be assessed whether an oxytocin-driven increase in activity in brain areas relevant to the task will facilitate social information processing and thus enhance task performance. Additionally it will be examined whether oxytocin can facilitate response inhibition in an emotional context.

Detailed Description

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Conditions

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The Impact of Oxytocin on Social Cognition

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Cross over Oxytocin and Placebo

fMRI measurement and blood examinations following 26 IU Oxytocin (Syntocinon) on day 1 and following placebo on day 14

Group Type EXPERIMENTAL

Oxytocin

Intervention Type DRUG

Placebo

Intervention Type DRUG

Cross over Placebo and Oxytocin

fMRI measurement and blood examinations following placebo on day 1 and following 26 IU Oxytocin (Syntocinon) on day 14

Group Type EXPERIMENTAL

Oxytocin

Intervention Type DRUG

Placebo

Intervention Type DRUG

Interventions

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Oxytocin

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* MRI- eligibility
* Subject's ability to fully grasp the type, scope and individual consequences of the study
* Willingness to participate in and comply with the study procedures as indicated by signing the dated informed consent form

Exclusion Criteria

* Left-handedness
* Smoking
* Regular intake of medication
* Hypersensitivity towards oxytocin or a chemically similar substance
* Current or previous neurological or psychiatric disorder
* Nose surgery or chronic sinus infection
* Any somatic disorder that may interfere with the experimental procedures, affect the outcome measures or pose a risk for the participant during performance of the experiment
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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RWTH Aachen University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University Hospital RWTH Aachen

Aachen, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Lisa Deuse

Role: CONTACT

Phone: 02418085692

Email: [email protected]

Sarah E Groppe

Role: CONTACT

Phone: 02418037151

Email: [email protected]

Facility Contacts

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Lisa Deuse

Role: primary

Other Identifiers

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EK163/13

Identifier Type: -

Identifier Source: org_study_id