Cocoa Flavanols and Exercise Capacity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-30

Study Completion Date

2013-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to characterize the potential improvement of cocoa flavanols on exercise capacity in highly trained cyclist. A placebo-controlled double-blinded randomized control study will be performed in 13 highly trained cyclist (crossover design). Participants will perform a baseline exercise testing on an ergometer. They will receive either a flavanol-poor or flavanol rich cocoa drink twice daily for one week before a second and third exercise testing is performed. The order of drinks is randomized and balanced (high-flavanol--\>low-flavanol drink or low-flavanol drink--\>high-flavanol drink)

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

High Flavonols Cocoa Intake for the Improvement of Body Fat Composition in Athletes

NCT04028128

Healthy Subjects

COMPLETED NA

Cocoa Flavanol Intake and Exercise in Hypoxia

NCT03135314

Hypoxia, Altitude

COMPLETED NA

Effects of Acute Intake of Flavanols on Cerebral Oxygenation and Cognition in Young Male Adults

NCT04374409

Healthy

COMPLETED NA

Impact of Cocoa Flavanols on Pulmonary Oxygen Uptake Kinetics and Exercise Tolerance in Sedentary Middle-aged Adults

NCT04370353

Aging Sedentary Behavior

COMPLETED NA

Interaction of Cocoa Methylxanthines With Cocoa Flavanol Related Vascular Effects

NCT02149238

Cardiovascular Diseases

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

13 participants (highly-trained cyclist, accustomed to exercise testing on ergometers will be enrolled (VO2max\>50 ml/kg, FMD \>5%, non-smokers, no medication, no diseases, age 20-36, male).

Baseline Testing:

Participants will perform a baseline testing consisting of an ergometric test with a step-wise increase of workload until exhaustion to determine lactate anaerobic threshold and cardio-pulmonary exercise capacity. Vascular function is monitored by Doppler Ultrasound.

In a second test, participants will perform a time trial (goal: as fast as possible)

Flavanol intervention Participants will twice daily receive either a flavanol-poor cocoa drink (13mg/dl)or a flavanol-rich cocoa drink (596mg/dl) over a period of 7 days. Order is randomized and balanced. Subjects will crossover to the second arm after a washout period of 7 days.

Testing performed on baseline day is repeated after the intake of both drinks

In a subgroup of n=6 participants, we will test whether the blood pressure cuff maneuver used for FMD will itself modify nitrite levels. For this the manuever will be completed 4 times and compared to n=6 untreated controls. in another subgroup 6 participants will receive 4times the maneuver but reperfusion will be limited by means of an ultrasound probe.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Exercise Capacity

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Flavanol rich cocoa

(596 mg), dissolved in water, twice daily intervention

Group Type EXPERIMENTAL

Cocoa

Intervention Type OTHER

dissolved in water twice-daily intervention

flavanol poor cocoa drink

( 13mg) dissolved in water, twice daily intervention

Group Type EXPERIMENTAL

Cocoa

Intervention Type OTHER

dissolved in water twice-daily intervention

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Cocoa

dissolved in water twice-daily intervention

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* highly trained cyclists (VO2 peak \> 50 ml/kg bodyweight)
* refrain from cocoa ingestion during trial
* training continued throughout testing
* \> 20 years
* male

Exclusion Criteria

* \> 36 years
* poor endothelial function
* acute infection
* any chronic heart or pulmonary disease
* arrhythmias
* acute or chronic renal failure
* smokers
* cardio-vascular risk factors : diabetes mellitus, hypertension, hyperlipidemia
* intake of nutrition supplements (l-arginine, creatinine)
* intake of WADA listed doping substances

Minimum Eligible Age

20 Years

Maximum Eligible Age

36 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes