Cocoa Flavanol and Coronary Vasomotion Vascular Function in Patients With Coronary Artery Disease
NCT ID: NCT02520466
Last Updated: 2019-01-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
37 participants
INTERVENTIONAL
2012-07-31
2018-12-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
DOUBLE
Study Groups
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flavanol-containing drink
flavanol-containing drink
flavanol-rich drink vs flavanol-free drink
Patients will be randomized to either a flavanol-rich drink or a flavanol-free drink of similar volume, taste and calory and sugar content
flavanol-free drink
flavanol-free drink matched for taste and calories
flavanol-rich drink vs flavanol-free drink
Patients will be randomized to either a flavanol-rich drink or a flavanol-free drink of similar volume, taste and calory and sugar content
Interventions
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flavanol-rich drink vs flavanol-free drink
Patients will be randomized to either a flavanol-rich drink or a flavanol-free drink of similar volume, taste and calory and sugar content
Eligibility Criteria
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Inclusion Criteria
* Age 20 - 80
* Written obtained informed consent
Exclusion Criteria
* Acute non-ST-elevation myocardial infarction (enzyme positive)
* Ventricular tachy-arrythmias or AV-Block \>I°
* Renal insufficiency (GFR MDRD \< 30ml/min) or liver disease (ALT or AST \>150 IU)
* Pregnancy
* Known allergy to compounds of cocoa product
* Known allergy to contrast media
* Known allergy to nuts
* Intolerance to coffein and theobromin
* Acute infectious disease
* Disease with systemic inflammation (e.g. rheumatoid arthritis, M. Crohn)
* Participation in another study within the last month
* Concomitant vitamin supplements and herbal remedies, as well as fruit and tea extracts
* No study visits ± 1 week before Eastern, Christmas and New Year holyday (altered eating habits)
* Extreme eating habits (as assessed by a questionnaire)
* Alcohol or drug abuse
* Lactose intolerance
20 Years
80 Years
ALL
No
Sponsors
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University of Zurich
OTHER
Responsible Party
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Principal Investigators
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Thomas F Lüscher, Prof MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital Zurich, Cardiovascular Center Cardiology
Locations
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Cardiovascular Center Cardiology Univeristy Hospital of Zurich
Zurich, , Switzerland
Universisty Hospital of Zurich, Cardiovascular Center Cardiology
Zurich, , Switzerland
Countries
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Other Identifiers
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EK2012-0201
Identifier Type: -
Identifier Source: org_study_id
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