Impact of Training Status on Bioavailability of Flavanones
NCT ID: NCT02627547
Last Updated: 2015-12-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
13 participants
INTERVENTIONAL
2013-09-30
2015-08-31
Brief Summary
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Endurance trained athletes will be invited to participate. Following screening procedures (a. Health Screening Questionnaire; b. height and weight measurement for calculation of Body Mass Index; c. maximal oxygen consumption (VO2max) uptake test, eligible participants will undertake two experimental tests; one during a period of normal training, the other immediately following 1 week of detraining.
In the morning of the experimental trial participants will consume 500 mL of orange juice. Blood samples and urinary fractions will be collected prior (base line) to and for 24 hours after orange juice consumption. Participants will be asked to follow a special polyphenol-free diet and record weighed dietary intake for 2 days preceding each trial and during the day of the experimental trial.
The study aims to:
1. Determine the effects of training status of endurance athletes on bioavailability of flavanones in endurance trained individuals
2. Determine whether changes in bioavailability of flavanones are related to changes in biomarkers of inflammation, oxidative stress, plasma lipids and insulin sensitivity.
Detailed Description
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Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Experimental tests
2 sets of experimental tests; once, during a period of normal training and repeated following one week of de-training
Normal training
5-10 hours of endurance training each week
De-training
No training
Interventions
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Normal training
5-10 hours of endurance training each week
De-training
No training
Eligibility Criteria
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Inclusion Criteria
* healthy
* normotensive
* non-smokers
* not taking any drug therapies
* VO2 max \>50 ml/kg body mass
Exclusion Criteria
* vegetarian
* unstable food habits
* VO2 max \< 50 ml/kg body mass
18 Years
MALE
Yes
Sponsors
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University of Glasgow
OTHER
Responsible Party
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Dr Dalia Malkova
Senior Lecturer
Principal Investigators
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Dalia Malkova
Role: PRINCIPAL_INVESTIGATOR
University of Glasgow
Locations
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University of Glasgow School of Medicine
Glasgow, , United Kingdom
Countries
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References
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Pereira-Caro G, Clifford MN, Polyviou T, Ludwig IA, Alfheeaid H, Moreno-Rojas JM, Garcia AL, Malkova D, Crozier A. Plasma pharmacokinetics of (poly)phenol metabolites and catabolites after ingestion of orange juice by endurance trained men. Free Radic Biol Med. 2020 Nov 20;160:784-795. doi: 10.1016/j.freeradbiomed.2020.09.007. Epub 2020 Sep 11.
Pereira-Caro G, Polyviou T, Ludwig IA, Nastase AM, Moreno-Rojas JM, Garcia AL, Malkova D, Crozier A. Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes. Am J Clin Nutr. 2017 Sep;106(3):791-800. doi: 10.3945/ajcn.116.149898. Epub 2017 Jul 26.
Other Identifiers
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200120075
Identifier Type: -
Identifier Source: org_study_id