Chronic Presence of Epstein Barr Virus in Sulcular and Junctional Epithelial Tissue From Gingiva is Associated With Severe Periodontitis

NCT ID: NCT01246648

Last Updated: 2024-06-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-17

Study Completion Date

2015-04-01

Brief Summary

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The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses. However it is thought that bacteria-induced pathogenesis is not sufficient alone to explain all biological and clinical features of the destructive periodontal disease. The main hypothesis is that herpesviruses, such as Epstein-Barr Virus, may participate as well by altering epithelial gingival cell biology and consequently may promote the initiation and progression of periodontitis.

Detailed Description

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Conditions

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Parodontitis Aggressive Parodontitis Chronic

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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chronic periodontitis

Group Type ACTIVE_COMPARATOR

Biopsy

Intervention Type PROCEDURE

dental extraction and gingival epithelial biopsy

agressive periodontitis

Group Type ACTIVE_COMPARATOR

biopsy

Intervention Type PROCEDURE

dental extraction and gingival epithelial biopsy

healthy patients

Group Type ACTIVE_COMPARATOR

Biopsy

Intervention Type PROCEDURE

dental extraction and gingival epithelial biopsy

Interventions

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Biopsy

dental extraction and gingival epithelial biopsy

Intervention Type PROCEDURE

biopsy

dental extraction and gingival epithelial biopsy

Intervention Type PROCEDURE

Biopsy

dental extraction and gingival epithelial biopsy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Men exclusively
* 12 years minimum
* 2 patients affected by chronic periodontitis
* 2 patients affected by aggressive periodontitis
* 2 healthy patients (orthodontics extraction)
* Subject who have read and understood the information note relative under investigation and who have signed the informed consent
* Subject whose legal representative signed the parental consent (if minor patient)

Exclusion Criteria

* Patient with contre-indication to dental extraction
* Patient witn serious blood disease
* Patient who exhibits systemic condition incompatible with the realization of the study
* Patient treated with oral retinoids, bisphosphonates, oral anticoagulants and anticonvulsivants
* Patient who presents za buccal carcinoma treated with radiotherapy
* Patient who have received during the past 6 months: anti-inflammatory drugs, anti-cancerous or immunosuppressive chemiotherapy
* Patient who presents a linguistic or psychic incapacity to understand information
* Female patient
Minimum Eligible Age

12 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Centre Hospitalier Universitaire de Nice

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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VINCENT Severine, PH

Role: PRINCIPAL_INVESTIGATOR

Centre Hospitalier Universitaire de Nice

Locations

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CHU de Nice, Hôpital Saint Roch

Nice, , France

Site Status

Countries

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France

Other Identifiers

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10-PP-13

Identifier Type: -

Identifier Source: org_study_id

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