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Transformation of Somatosensory and Visual Coordinate Systems

NCT ID: NCT01177462

Last Updated: 2013-09-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-03-31

Brief Summary

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Manipulation of object is a multisensory experience that includes tactile motion between the object and the fingerpad, visual motion elicited by the motion the object and the movement of the hand, and the active motor commend to control upper limb and hand conformation. It remains to be determined how such a complex interaction between touch and vision could be achieved effortlessly. In the present study, we will investigate how the motion information is transformed between touch and vision using the most novel approaches in human psychophysics, neuropsychology and monkey neurophysiology. Specifically, we will present tactile motion on primate fingerpads using a recently developed ball stimulator with a design in which we vary the direction of motion with respect to the skin surface and also vary the hand conformation and position. This setup allows us to systematically sample the possible scenarios involving coordinate transformation between the somatosensory and visual systems in conditions that could occur in hand exploration and object manipulation in daily life. We will present these tactile stimuli on normal human subject as well as stroke patients such as patients with spatial hemineglect. Finally, we will record from macaque monkeys in cortical areas that are thought to underlie the transformation of coordinates, such as the primary somatosensory cortex and posterior parietal cortex. The results of the present study will contribute to the understanding of multisensory integration and the rehabilitation for patients with impaired use of spatial information.

Detailed Description

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Conditions

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Stroke

Keywords

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coordinate system normal

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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hemineglect stroke patients

Stroke patients with hemineglect

No interventions assigned to this group

Control stroke patients

Stroke patients without hemineglect

No interventions assigned to this group

Normal control

Normal subjects

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* stroke patients
* stable medical condition
* can cooperate in evaluation

Exclusion Criteria

* peripheral neuropathy
* limb ambulation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Chang Gung Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Yu-Cheng Pei

Attending Physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yu-Cheng Pei, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Chang Gung Memorial Hospital

Locations

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Chang Gung Memorial Hospital

Taoyuan, Taiwan, Taiwan

Site Status RECRUITING

Countries

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Taiwan

Facility Contacts

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Yu-Cheng Pei, MD PhD

Role: primary

Other Identifiers

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CMRPG590021G

Identifier Type: -

Identifier Source: org_study_id