Pilot Study of Remote Ischemic Preconditioning in Heart Failure
NCT ID: NCT01128790
Last Updated: 2013-12-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
22 participants
INTERVENTIONAL
2009-10-31
2011-06-30
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
TRIPLE
Study Groups
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remote ischemic preconditioning
4 cycles of 5 mins upper limb ischemia induced by blood pressure cuff inflation 20mmHg above systolic blood pressure
Remote ischemic preconditioning
4 cycles x 5 mins upper limb blood pressure cuff inflation 20mmHg above systolic blood pressure
Sham control
4 x 5 mins of upper limb blood pressure cuff inflation to 10mmHg (non-occlusive)
Sham Control
4 cycles x 5mins blood pressure cuff inflation to 10mmHg
Interventions
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Remote ischemic preconditioning
4 cycles x 5 mins upper limb blood pressure cuff inflation 20mmHg above systolic blood pressure
Sham Control
4 cycles x 5mins blood pressure cuff inflation to 10mmHg
Eligibility Criteria
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Inclusion Criteria
* NYHA functional class II-IV
* Non ischemic cardiomyopathy
* Stable
Exclusion Criteria
* ischemic cardiomyopathy
* diabetes mellitus
* peripheral neuropathy
* ventricular assist device
* contraindications to exercise stress testing
18 Years
ALL
No
Sponsors
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The Hospital for Sick Children
OTHER
University Health Network, Toronto
OTHER
Responsible Party
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Locations
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Toronto General Hospital
Toronto, Ontario, Canada
Countries
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References
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Brindle HE, Tetsa-Tata D, Edwards T, Choi EM, Kasonia K, Aboubacar S, Mambula G, Kavunga-Membo H, Grais R, Johnson J, Bausch DG, Muyembe-Tamfum JJ, Ama IS, Lees S, Watson-Jones D, Camacho A, Roberts CH. Using an analogue-digital hybrid clinical data management platform during a two-dose preventive Ebola virus vaccine trial in Goma, the Democratic Republic of the Congo. PLOS Glob Public Health. 2025 May 2;5(5):e0004487. doi: 10.1371/journal.pgph.0004487. eCollection 2025.
McDonald MA, Braga JR, Li J, Manlhiot C, Ross HJ, Redington AN. A randomized pilot trial of remote ischemic preconditioning in heart failure with reduced ejection fraction. PLoS One. 2014 Sep 2;9(9):e105361. doi: 10.1371/journal.pone.0105361. eCollection 2014.
Other Identifiers
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09-0550-BE
Identifier Type: -
Identifier Source: org_study_id