Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
63 participants
INTERVENTIONAL
2020-05-31
2022-05-31
Brief Summary
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Detailed Description
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Exercise training sessions will consist in a continue bicycle exercise test at 70 to 80 % of the maximal heart rate, while breathing (single blind) normoxia or hypoxia gaz.
Rest conditioning consist in a one hour of rest, while breathing (single blind) normoxia or hypoxia gaz.
For hypoxia sessions, the oxygen saturation target will be fo 85-90 % for the 4 first weeks and 80-85 % for the last 4 weeks.
Three arms :
* exercise training in NORMOXIA and rest conditioning in NORMOXIA
* exercise training in HYPOXIA and rest conditioning in NORMOXIA
* exercise training in NORMOXIA and rest conditioning in HYPOXIA
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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normoxia conditioning
exercise training in normoxia and rest conditioning in normoxia
hypoxia air
Normobaric hypoxia is generated by adding azote in normal air to decrease the oxygen availability.
exercise hypoxia
exercise training in hypoxia and rest conditioning in normoxia
hypoxia air
Normobaric hypoxia is generated by adding azote in normal air to decrease the oxygen availability.
rest hypoxia
exercise training in normoxia and rest conditioning in hypoxia
hypoxia air
Normobaric hypoxia is generated by adding azote in normal air to decrease the oxygen availability.
Interventions
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hypoxia air
Normobaric hypoxia is generated by adding azote in normal air to decrease the oxygen availability.
Eligibility Criteria
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Inclusion Criteria
* stable heart failure state I-II New York Heart Association (NYHA) with altered ejection fraction (EF ≤ 40 %)
* signed informed consent
Exclusion Criteria
* right ventricle dysfunction
* uncontrolled arrythmias
* rest elevated in pulmonary artery pressure (≥ 45 mmHg)
* migraine
* high altitude trip above 2500 m high during study period
* impossibility to realise a maximal bicycle exercise test
20 Years
70 Years
ALL
No
Sponsors
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University Hospital, Grenoble
OTHER
Responsible Party
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Locations
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University Hospital
Grenoble, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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38RC17.347
Identifier Type: -
Identifier Source: org_study_id
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