The Acute Effects of Oleic Acid Enriched-diets on Lipids, Insulin Sensitivity and Serum Inflammatory Markers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-08-31

Study Completion Date

2009-09-30

Brief Summary

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Objectives: To investigate the acute effects of olive oil, palm olein and lard on lipid profile, insulin sensitivity and inflammatory markers.

Hypothesis: Different dietary fats will alter lipid profile, insulin sensitivity and inflammatory markers postprandially.

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Detailed Description

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A randomized, single blind, crossover design was undertaken to test meals enriched with palm olein vs olive oil vs lard. Volunteers were asked to participate in three postprandial challenges, separated by at least 3-days. Subjects were provided a low fat meal(\<10g fat) the day before the intervention. Fasting blood was collected the next day and the subjects were instructed to consume test meals (50g high fat meal). Further venous blood was collected at 30 min, 1h, 2h, 3h and 4h postprandially.

Primary outcome variable: Triacylglycerol (TAG) Secondary outcome variables: Insulin sensitivity (glucose, insulin), non esterified fatty acids (NEFA), inflammatory markers

Conditions

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Lipid Profile

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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palm olein

Group Type EXPERIMENTAL

The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers

Intervention Type DIETARY_SUPPLEMENT

olive oil

Group Type EXPERIMENTAL

The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers

Intervention Type DIETARY_SUPPLEMENT

lard

Group Type EXPERIMENTAL

The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers

Intervention Type DIETARY_SUPPLEMENT

Interventions

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The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Age: 18-45 years
* BMI : 18.5-30 kg/m\^2
* Healthy, men

Exclusion Criteria

* medical history of cardiovascular disease, cancer, diabetes or chronic diseases
* BMI \< 18.5 OR \> 30 kg/m\^2
* waist hip ratio \> 0.9
* total cholesterol \> 5.2 mmol/L
* triacylglycerol (TAG) \> 2.2 mmol/L
* current use of antihypertensive or lipid lowering medication

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes