Effect of Oleic Acid on Inflammation Markers and Blood Lipid Metabolites: A Randomised, Double-Blind, Crossover Study

NCT ID: NCT00715312

Last Updated: 2008-07-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

43 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-02-29

Study Completion Date

2008-06-30

Brief Summary

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Rationale: The effect of positional distribution of dietary fatty acids on markers of inflammation and blood lipids metabolites on diets containing fatty acids such as oleic acid that are associated with reduced risk of cardiovascular disease is not widely studied.

Hypothesis: There would be difference detected in the concentrations of markers of inflammation and blood lipid metabolites in human volunteers fed controlled diets.

Study design: A randomized, double-blind, crossover clinical trial that involves 41 healthy volunteers. The volunteers will be selected based on inclusion and exclusion criteria. They will consume controlled diets for 5 weeks that provides 15% of energy from protein, 30% of energy from fat, and 55% of energy from carbohydrates. Volunteers will be assigned to each test diets which is cooked with novel olein, palm stearin or partially hydrogenated soybean oil in random order until all three diets has consumed by each person.

Main study parameters: LDL-cholesterol

Detailed Description

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Conditions

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Inflammation

Keywords

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Inflammation LDL Oleic acid Palmitic acid trans fatty acid C-reactive protein

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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A

Group Type EXPERIMENTAL

Novel Olein

Intervention Type OTHER

A total of 70g of test oil is incorporated into cooked meal which accounts for 30-35% of calorie intake

Novel Olein

Intervention Type OTHER

A total of 70g of test oil is incorporated into cooked meal which provides 30-35% of calorie

Interventions

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Novel Olein

A total of 70g of test oil is incorporated into cooked meal which accounts for 30-35% of calorie intake

Intervention Type OTHER

Novel Olein

A total of 70g of test oil is incorporated into cooked meal which provides 30-35% of calorie

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy and free from any disease and absence of family history for arteriosclerosis or hypertension
* Not on any medication or supplements or weight loss program
* Non smokers and alcoholics

Exclusion Criteria

* Having some health-related problems e.g fever, flu, allergy, chronic diseases
* On some treatment or medication
* Smokers and alcoholics
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Malaysia Palm Oil Board

OTHER_GOV

Sponsor Role lead

Responsible Party

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Malaysian Palm Oil Board (MPOB)

Principal Investigators

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Teng Kim Tiu

Role: PRINCIPAL_INVESTIGATOR

Malaysia Palm Oil Board

Locations

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Malaysia Palm Oil Board

Kajang, Selangor, Malaysia

Site Status

Countries

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Malaysia

Other Identifiers

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625.9

Identifier Type: -

Identifier Source: org_study_id