Effect of Garlic on Inflammatory Mediators

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Clinical Phase

PHASE4

Total Enrollment

34 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-04-30

Study Completion Date

2007-03-31

Brief Summary

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This research will investigate the effect of garlic oil extract when added to daily diet on inflammatory mediators and blood clotting activation.

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Detailed Description

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To investigate the pharmacokinetics of one of the garlic oil macerate, Ajoene, the anti-inflammatory effect of garlic oil macerate on the pro-inflammatory transcription factor NF-kB, it's activating proteins, including IkB, IkB Kinases a and B (IKKa and IKKB) and the pro-inflammatory NF-kB-regulated proteins, c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), plasminogen activated protein-1 (PAI-1)and the effect of garlic oil macerate intake on platelet activation in normal subjects.

Conditions

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Healthy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Garlic Oil Macerate

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 18 years of age and older
* Normal subjects with BMI \<25, obese subjects with BMI \>30
* Subjects who have consented to adhere to the diet, regular weekly visits, and blood draws.

Exclusion Criteria

* Subjects on any antioxidant medication.
* Patient on non-steroidal anti-inflammatory drug.
* On any agent with antioxidant properties.
* History of drug or alcohol abuse.
* Any life threatening disease.
* On any agent with significant antioxidant properties.
* Taking garlic extracts in the diet regularly.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes