Study of Macroplastique Safety and Effectiveness in the Treatment of Female Stress Urinary Incontinence

NCT ID: NCT01115465

Last Updated: 2020-03-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

276 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-01-31

Study Completion Date

2022-02-28

Brief Summary

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The ROSE Registry will determine the long-term safety and effectiveness of Macroplastique in the treatment of female stress urinary incontinence (SUI) due to intrinsic sphincter deficiency (ISD).

Detailed Description

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The Rose Registry is a five-year post-market study of the safety and effectiveness of Macroplastique in the treatment of female stress urinary incontinence due to intrinsic sphincter deficiency.

Conditions

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Stress Urinary Incontinence

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Macroplastique

Macroplastique will be used for the treatment in an open-label, five year, post-market study

Group Type OTHER

Macroplastique

Intervention Type DEVICE

Macroplastique is an injectable soft-tissue bulking agent used to treat stress urinary incontinence (SUI) primarily due to intrinsic sphincter deficiency (ISD).

Interventions

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Macroplastique

Macroplastique is an injectable soft-tissue bulking agent used to treat stress urinary incontinence (SUI) primarily due to intrinsic sphincter deficiency (ISD).

Intervention Type DEVICE

Other Intervention Names

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polydimethylsiloxane PDMS

Eligibility Criteria

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Inclusion Criteria

* Subject has signed written informed consent
* Subject is a female at least 18 years of age
* Subject has been diagnosed with SUI primarily due to intrinsic sphincter deficiency (ISD)
* Subject understands all study requirements including five year follow-up schedule
* Subject is psychologically stable and suitable for intervention as determined by the Investigator

Exclusion Criteria

* Subject has an acute urogenital tract inflammation or infection
* Subject is pregnant or intends to become pregnant within one year
* Subject has had a sling placement within 12 weeks
* Subject has had a bulking agent treatment within 12 weeks
* Subject has a bladder neck or urethral stricture, gross utero-vaginal prolapse, untreated detrusor instability or hyperreflexia, neuropathic bladder, or overflow incontinence
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Uroplasty, Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Urological Associates of Southern Arizona

Tucson, Arizona, United States

Site Status

Kaiser Permanente Southern California-Irvine Medical Center

Irvine, California, United States

Site Status

Univeristy of California- Irvine

Orange, California, United States

Site Status

The University of California- of San Diego

San Diego, California, United States

Site Status

Urology Associates, PC

Englewood, Colorado, United States

Site Status

Specialists in Urology

Naples, Florida, United States

Site Status

The Florida Bladder Institute

Naples, Florida, United States

Site Status

Northwestern University Prentice Women's Hospital

Chicago, Illinois, United States

Site Status

Deaconess Clinic

Newburgh, Indiana, United States

Site Status

The University of Michigan Health Center

Ann Arbor, Michigan, United States

Site Status

Mercy Heatlh Partners at the Lakes

Muskegon, Michigan, United States

Site Status

Western New York Urology

Cheektowaga, New York, United States

Site Status

Western Carolina Women's Specialty Center

Asheville, North Carolina, United States

Site Status

Carolina Urology Partners

Gastonia, North Carolina, United States

Site Status

University of Oklahoma

Oklahoma City, Oklahoma, United States

Site Status

Oregon Health & Science University

Portland, Oregon, United States

Site Status

Southern Urogynecology

Columbia, South Carolina, United States

Site Status

Urology of Virginia

Virginia Beach, Virginia, United States

Site Status

Athena Urology

Issaquah, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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MPQ092006

Identifier Type: -

Identifier Source: org_study_id

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