Value of Urodynamics Prior to Stress Incontinence Surgery 2

NCT ID: NCT00814749

Last Updated: 2008-12-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

600 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-11-30

Study Completion Date

2011-01-31

Brief Summary

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To test the value of preoperatively performed urodynamics with regard to outcome of surgery for stress urinary incontinence (SUI) and to examine whether not performing urodynamics preoperatively is more cost effective than performing urodynamics preoperatively using the non-inferiority assumption.

Detailed Description

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Conditions

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Stress Urinary Incontinence

Keywords

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stress urinary incontinence urodynamics randomized clinical trial surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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surgical therapy

Group Type ACTIVE_COMPARATOR

midureteral sling

Intervention Type PROCEDURE

midureteral sling

individual management

Group Type ACTIVE_COMPARATOR

surgical therapy or conservative

Intervention Type OTHER

midureteral sling or conservative; medication, physiotherapy

Interventions

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midureteral sling

midureteral sling

Intervention Type PROCEDURE

surgical therapy or conservative

midureteral sling or conservative; medication, physiotherapy

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Symptoms of stress urinary incontinence and/or mixed urinary incontinence, predominantly stress incontinence
* Signs of stress urinary incontinence on physical examination or voiding-diary
* Patient is a candidate for surgical treatment (as based on history and physical examination)
* Patient has attended at least 3 months of physiotherapy
* Patient accepts randomisation
* Patient is capable to fill out bladder diary's, pad tests and questionnaires
* Patient understands the Dutch written and spoken language
* ASA 1 or 2

Exclusion Criteria

* Previous incontinence surgery
* Mixed urinary incontinence, urge component is predominant
* Prolapse \>= 1cm beyond the hymen on Valsalva in supine position
* Postvoid urinary residual \> 150ml
* Present urinary tract infection
* The need for additional pelvic surgery (prolapse and/or hysterectomy)
* Patient is or wants to become pregnant
* Prior pelvic radiotherapy
Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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ZonMw: The Netherlands Organisation for Health Research and Development

OTHER

Sponsor Role collaborator

Radboud University Medical Center

OTHER

Sponsor Role lead

Principal Investigators

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Mark Vierhout, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Radboud University Medical Center

John Heesakkers, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Medical Center St. Radboud

Kirsten Kluivers, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Medical Center St. Radboud

Sanne van Leijsen, MD

Role: PRINCIPAL_INVESTIGATOR

University Medical Center St. Radboud

Ben Willem Mol, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Academic Medical Centre Amsterdam

Locations

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University Medical Center St. Radboud

Nijmegen, Gelderland, Netherlands

Site Status RECRUITING

Countries

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Netherlands

Central Contacts

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Sanne van Leijsen, M.D.

Role: CONTACT

Phone: +31-6-41520114

Email: [email protected]

Mark Vierhout, M.D. PhD

Role: CONTACT

Phone: +31243613635

Email: [email protected]

Facility Contacts

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Sanne van Leijsen, MD

Role: primary

References

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van Leijsen SAL, Kluivers KB, Mol BWJ, Hout J', Milani AL, Roovers JWR, Boon JD, Vaart CHV, Langen PH, Hartog FE, Dietz V, Tiersma ESM, Hovius MC, Bongers MY, Spaans W, Heesakkers JPFA, Vierhout ME; Dutch Urogynecology Consortium*. Value of urodynamics before stress urinary incontinence surgery: a randomized controlled trial. Obstet Gynecol. 2013 May;121(5):999-1008. doi: 10.1097/AOG.0b013e31828c68e3.

Reference Type DERIVED
PMID: 23635736 (View on PubMed)

van Leijsen SA, Kluivers KB, Mol BW, Broekhuis SR, Milani FL, van der Vaart CH, Roovers JP, Bongers MY, den Boon J, Spaans WA, de Leeuw JW, Dietz V, Kleinjan JH, Brolmann HA, Roos EJ, Schaafstra J, Heesakkers JP, Vierhout ME. Protocol for the value of urodynamics prior to stress incontinence surgery (VUSIS) study: a multicenter randomized controlled trial to assess the cost effectiveness of urodynamics in women with symptoms of stress urinary incontinence in whom surgical treatment is considered. BMC Womens Health. 2009 Jul 21;9:22. doi: 10.1186/1472-6874-9-22.

Reference Type DERIVED
PMID: 19622153 (View on PubMed)

Other Identifiers

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2006/197

Identifier Type: -

Identifier Source: org_study_id