Pharmacokinetic Evaluation of Fluoroquinolone Antibiotics Administered Intravenously in Intensive Care Patients With Normal Renal Function and With Renal Hyperfiltration
NCT ID: NCT01109823
Last Updated: 2021-06-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
14 participants
INTERVENTIONAL
2010-05-19
2013-12-01
Brief Summary
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Adequate blood levels are required for a good efficacy of the antibiotic. Due to the fact that levofloxacin is almost completely eliminated renally, the blood levels for this antibiotic are strongly influenced by the renal function. Therefore, this study aims to evaluate the pharmacokinetics of levofloxacin in patients with hyperfiltration, in comparison with critically ill patients with normal renal function.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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patients with normal renal function
Patients with normal renal function hospitalized at the Department Intensive Care Unit who are being treated with levofloxacin I.V. (500mg, twice daily) for an infection.
intravenous administration of levofloxacin
Intravenous administration of levofloxacin is used.
patients with hyperfiltration
Patients with hyperfiltration hospitalized at the Department Intensive Care Unit who are being treated with levofloxacin I.V. (500mg, twice daily) for an infection.
intravenous administration of levofloxacin
Intravenous administration of levofloxacin is used.
Interventions
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intravenous administration of levofloxacin
Intravenous administration of levofloxacin is used.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* No informed consent
* No arterial catheter
* Hematocrit ≤ 21
* Pregnancy and lactation
* Creatinine clearance \< 80 ml/min
18 Years
ALL
No
Sponsors
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University Ghent
OTHER
Responsible Party
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Principal Investigators
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Jan Van Bocxlaer, PhD
Role: PRINCIPAL_INVESTIGATOR
University Ghent
Locations
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University Ghent
Ghent, , Belgium
University Hospital Ghent
Ghent, , Belgium
Countries
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Other Identifiers
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2010/167
Identifier Type: -
Identifier Source: org_study_id
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