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Assessment of Kidney Function and Osteomuscular Status After Critical Care

NCT ID: NCT04980092

Last Updated: 2025-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-03-01

Study Completion Date

2027-01-31

Brief Summary

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This observational study aims to assess kidney function through direct glomerular filtration rate (GFR) using iohexol clearance, compared to estimated GFR based on creatinine and cystatin C equations. Kidney function will also be evaluated through renal fibrosis biomarkers. Kidney function will be correlated to body composition, muscle turnover biomarkers, and bone micro-architecture.

Detailed Description

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The investigators developed a post-ICU clinic where complications of the post-intensive care syndrome are detected. Muscle function is assessed by clinical testings, muscle strength measurement. Body composition is measured by electrical bioimpedance. Bone mass is assessed using dual-energy radiographic absorptiometry.

It is well known that ICU survivors experience a loss of muscle mass. This can lead to misinterpretation of estimated GFR based on creatinine equations.

The aim of the present study is to assess the evolution of kidney function after a prolonged stay in ICU, using GFR equations based on cystatin C, and to compare it to measured GFR using iohexol clearance.

The second aim is to explore the evolution of bone and muscle health in these patients.

Conditions

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Critical Illness Kidney Injury Muscle Loss Bone Loss

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Post-ICU group

Observational foolow-up

one-year follow-up

Intervention Type OTHER

patients will be followed during the year after ICU discharge, in order to assess kidney function, and muscle and bone health

Interventions

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one-year follow-up

patients will be followed during the year after ICU discharge, in order to assess kidney function, and muscle and bone health

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients surviving an ICU stay of at least 7 days
* patients who experienced acute kidney injury (KDIGO criteria) during ICU stay

Exclusion Criteria

* chronic kidney injury with dedicated follow-up before ICU admission
* chronic extrarenal epuration
* kidney transplant
* allergy to iohexol
* iodinated contrast allergy
* refusal
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Liege

OTHER

Sponsor Role lead

Responsible Party

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Anne-Françoise Rousseau

Head of Clinic

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anne-Françoise Rousseau, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University hospital of Liège

Locations

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University Hospital of Liège

Liège, Liège, Belgium

Site Status

Countries

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Belgium

Other Identifiers

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ROPS

Identifier Type: -

Identifier Source: org_study_id