Prescription Strategies of Amikacin in Intensive Care Patients on Renal Replacement Therapy: an Observational Prospective Multicenter Study

NCT ID: NCT04322019

Last Updated: 2022-06-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

112 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-05-25

Study Completion Date

2022-05-16

Brief Summary

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Amikacin is the aminoglycoside of choice for treatment of severe infections in intensive care. An achievement of its objectives in pharmacokinetics and pharmacodynamics is difficult in intensive care patients because of modification of their volume of distribution and renal clearance. Acute renal failure requiring renal replacement therapy is frequent in intensive care. Extrarenal purification modalities (continuous versus intermittent, type of dialysis membrane), which can influence amikacin clearance, are multiple and teams dependent. Guidelines of good practice for Amikacin in intensive care patients do not exist.

Detailed Description

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The aim of this study is to describe strategies of prescription and monitoring of Amikacin in intensive care patients on renal replacement therapy.

Conditions

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Amikacin Treatment

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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"Amikacin treatment" group

Intensive care patients on renal replacement therapy with Amikacin treatment

Data record

Intervention Type OTHER

Data record

Interventions

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Data record

Data record

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients in intensive care
* patients on extrarenal replacement
* patients with Amikacin treatment
* patients accepting to participate in the study

Exclusion Criteria

* patients less than 18 years old
* pregnant women
* patients with Amikacin treatment in the previous 7 days
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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CHU de Reims

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Damien JOLLY

Reims, , France

Site Status

Countries

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France

Other Identifiers

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PO20032

Identifier Type: -

Identifier Source: org_study_id

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