Elimination of Antibiotics During Citrate-anticoagulated Continuous-veno-venous-haemodialysis

NCT ID: NCT02533609

Last Updated: 2020-05-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-09-30

Study Completion Date

2020-12-31

Brief Summary

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Acute kidney injury (AKI) requiring renal replacement therapy is common in critically ill patients. The major causes of AKI are severe sepsis and septic shock requiring effective antibiotic treatment. Patients with sepsis on ICUs usually are haemodynamically instable so that renal replacement therapy is applied using continuous techniques. In recent years, the efficacy of renal replacement therapies has improved, namely by using regional citrate anticoagulation which improves filter lifetime and filter patency. At present, the extent of removal of antibiotic drugs using citrate-anticoagulated CVVHD in critically ill patients has not been investigated thoroughly. Thus, the investigators want to investigate

1. whether and to what extent antibiotic drugs (piperacillin/tazobactam and imipenem/cilastatin) are removed during citrate-anticoagulated CVVHD per se
2. whether filter patency during citrate-anticoagulated CVVD remains stable during a treatment period of 72 h

Detailed Description

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Conditions

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Acute Kidney Injury Bacterial Infection

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Piperacillin/Tazobactam

Patients undergoing continuous veno-venous renal replacement therapy and treated with this antibiotics

No interventions assigned to this group

Imipenem/Cilastatin

Patients undergoing continuous veno-venous renal replacement therapy and treated with this antibiotics

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Intensive care patients with acute kidney injury requiring continous renal replacement therapy with citrate-anticoagulation
* Age \> 18 y

Exclusion Criteria

* \< 18 y
* Pregnancy
* Contraindications against citrate-anticoagulation or continous renal replacement therapy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fresenius Medical Care Deutschland GmbH

INDUSTRY

Sponsor Role collaborator

Heinrich-Heine University, Duesseldorf

OTHER

Sponsor Role lead

Responsible Party

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Klinik für Anästhesiologie

Prof. Dr. D. Kindgen-Milles

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Detlef Kindgen-Milles, Prof.

Role: STUDY_DIRECTOR

Department of Anesthesiology

Locations

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Prof. Kindgen-Milles

Düsseldorf, , Germany

Site Status

Countries

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Germany

Other Identifiers

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2015-02-ENDVERSION

Identifier Type: -

Identifier Source: org_study_id

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