LXRs, Cholesterol Metabolism and Uterine Dystocia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Total Enrollment

58 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-04-30

Study Completion Date

2015-09-03

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Despite the fact that a link between cholesterol and the myometrium has been clearly established, no study investigating aspects of cholesterol metabolism and uterine dystocia currently exists. This study is a pilot study whose aim is to test the hypothesis that an association between uterine dystocia and single-nucleotide polymorphisms (SNPs) in the genes coding for the LXRs.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Non-invasive Placental Chromosome Exploration of Intrauterine Growth Restriction

NCT05023161

Fetal Growth Retardation

RECRUITING

Ultra-early Identification of Fetal Chromosomal Characteristics From Extravillous-trophoblast Cells

NCT06523543

Pregnant Women

RECRUITING

Neonatal Outcome of Children With Antenatal Colic Hyperechogenicity

NCT04983069

Colic Nephropathy

UNKNOWN

Phospholipase A2 Producing Bacteria and Pre-Term Labor

NCT00855543

Preterm Labor

COMPLETED

ABCB4 Gene Mutations in Intrahepatic Cholestasis of Pregnancy and Controls

NCT00700232

Intrahepatic Cholestasis of Pregnancy

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Uterine Inertia Dystocia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Group 1

Control group: these patients have mechanical dystocia; cholesterol metabolism factors are a priori not involved.

Whole blood sampling

Intervention Type BIOLOGICAL

Whole blood sampling for SNP polymorphism analysis

Group 2

These patients have uterine dystocia

Whole blood sampling

Intervention Type BIOLOGICAL

Whole blood sampling for SNP polymorphism analysis

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Whole blood sampling

Whole blood sampling for SNP polymorphism analysis

Intervention Type BIOLOGICAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients undergoing C-section for a dystocia: 2 to 3 hours of stagnation in labor progress are observed (ie no increasing dilation, and uterine contractions less that 3-5 per 10 minutes) in spite of measures taken to overcome dystocia (oxytocin injection and artificial breaking of waters)
* the child is alive
* the child does not have apriori known malformations that could interfere with a vaginal birth
* foetus in cephalic position
* full term pregnancy (\>= 37 weeks of amenorrhea)
* single birth
* patient has signed consent
* patient is affiliated with a social security system

Exclusion Criteria

* vaginal birth
* programmed C-section
* C-section is chosen because the fetus has a cardia rhythm problem, and there is no stagnation in the labor process
* multiple pregnancy
* the child is in a breech position
* premature birth (\<37 weeks amenorrhea)
* in utero fetal death
* fetal malformation known before birth that could interfere with a vaginal birth
* non french-speaking patient (impossible to correctly inform the patient)
* patient under guardianship

Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No