ABCB4 Gene Mutations in Intrahepatic Cholestasis of Pregnancy and Controls
NCT ID: NCT00700232
Last Updated: 2010-06-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
120 participants
OBSERVATIONAL
2006-07-31
2009-07-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
The aim of the present study is to describe the nature and frequency of these mutations in a series of patients with intrahepatic cholestasis of pregnancy and to compare with a control group of pregnant women without intrahepatic cholestasis of pregnancy.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Genetic Polymorphisms of ABCB11 and ABCB4 in Women With Intrahepatic Cholestasis of Pregnancy (ICP) and in Their First Degree Relatives
NCT04281082
Ursodeoxycholic Acid And Cholestasis Of Pregnancy
NCT01226823
Association of Intrahepatic Cholestasis of Pregnancy and Chronic Placental Inflammation
NCT05197387
Bile Acids Metabolism and Genetic Mutation Profile in the ICP in the Indian Population
NCT05691036
Predictors of Adverse Neonatal Outcomes in Intrahepatic Cholestasis of Pregnancy
NCT04922580
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
The entire ABCB4 gene coding sequence and the promoter region were analyzed, during the routine medical management, by single strand conformation polymorphism and/or sequencing in 50 unrelated Caucasian patients with intrahepatic cholestasis of pregnancy.
The genomic variants detected in these patients with intrahepatic cholestasis of pregnancy will be sought in 100 control women from Caucasian origin recruited in the same hospital.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
COHORT
PROSPECTIVE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
1
Normal multiparous pregnant women without intrahepatic cholestasis of pregnancy (control group)
No interventions assigned to this group
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* caucasian and born in France
* multiparous (with at least 2 full term pregnancies)
* with informed written consent
Exclusion Criteria
* liver disease secondary to oral contraception
* Chronic liver disease
* disease during current pregnancy
18 Years
FEMALE
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
University Hospital, Tours
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
University Hospital, Tours
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
BACQ Yannick, MD
Role: STUDY_DIRECTOR
Service d'hépato-gastro-entérologie CHRU Tours
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Service de Gynécologie Obstétrique CHRU Tours
Tours, , France
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
AOHP06-YB GEN CIG
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.