P-wave Duration and Dispersion in Intrahepatic Cholestasis of Pregnancy
NCT ID: NCT01906827
Last Updated: 2014-03-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
90 participants
OBSERVATIONAL
2013-07-31
2014-06-30
Brief Summary
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Detailed Description
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Bile acids increases both maternal and fetal circulation in ICP. The bile acids has been demonstrated to cause arrhythmia and abnormal calcium dynamics in cultured neonatal rat cardiomyocytes. Raised maternal bile acid levels have been associated with fetal distress and arrhytmia in fetus.
P-wave dispersion (PWD) is defined as the difference between the maximum and the minimum P-wave durations measured on a 12-lead surface electrocardiogram (ECG). Increased P-wave duration and PWD have been reported in various clinical settings, including atrial flutter, coronary artery disease, hypertension, rheumatic mitral stenosis, mitral annular calcification, obstructive sleep apnea, and obesity.
So the investigators think that bile acids may alter maternal cardiomyocyte function as fetus. The investigators hypothesized that PWD and p wave duration may affect in pregnancy with ICP.
The aim of this study is to investigate maternal P-wave duration and dispersion changes in pregnant women with intrahepatic cholestasis of pregnancy .
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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pregnant with ICP
pregnant with ICP
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Disease during current pregnancy
* Multiple pregnancies
18 Years
39 Years
FEMALE
Yes
Sponsors
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Zekai Tahir Burak Women's Health Research and Education Hospital
OTHER
Responsible Party
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Ayse Kirbas
ayse kirbas
Principal Investigators
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ayse kirbas, md
Role: PRINCIPAL_INVESTIGATOR
Zekai Tahir Burak Women's Health Research and Education Hospital
ozgur kirbas, md
Role: PRINCIPAL_INVESTIGATOR
Yuksek Ihtisas Hospital
Locations
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Zekai Tahir Burak Maternity Teaching Hospital
Ankara, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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ozgur kirbas, md
Role: backup
Other Identifiers
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zekai tahir burak- p wave
Identifier Type: -
Identifier Source: org_study_id
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