Portal Vein Pulsatility Flow in Pregnancy

NCT ID: NCT04429178

Last Updated: 2022-03-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-08-13

Study Completion Date

2022-03-01

Brief Summary

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This study is to investigate if portal vein pulsatility fraction can be measured in pregnancy and if it increases during the course of pregnancy as would be expected by the physiologic increase in blood volume that happens during pregnancy. Portal vein pulsatility fraction is measured in non-pregnant controls and in women in the 1st, 2nd and 3rd trimester of pregnancy.

Detailed Description

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Conditions

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Pregnancy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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women in the 1st trimester of pregnancy.

ultrasound

Intervention Type OTHER

portal vein pulsatility fraction (percent) measured with ultrasound

women in the 2nd trimester of pregnancy.

ultrasound

Intervention Type OTHER

portal vein pulsatility fraction (percent) measured with ultrasound

women in the 3rd trimester of pregnancy.

ultrasound

Intervention Type OTHER

portal vein pulsatility fraction (percent) measured with ultrasound

non-pregnant women

ultrasound

Intervention Type OTHER

portal vein pulsatility fraction (percent) measured with ultrasound

Interventions

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ultrasound

portal vein pulsatility fraction (percent) measured with ultrasound

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Ability to give informed consent
* American Society of Anesthesiologists (ASA) Class I and II
* Singleton pregnancy during 1st, 2nd or 3rd trimester or healthy non-pregnant females of childbearing age as controls

Exclusion Criteria

* Inability to give informed consent
* Multiple gestation
* Significant co-morbidities (e.g. cardiac abnormalities, cardiac dysfunction, arrhythmias, severe asthma, renal insufficiency)
* High risk pregnancies (e.g. pre-eclampsia, gestational hypertension, HELLP, gestational diabetes)
* Body-Mass-Index (BMI) \< 18kg/m2 or \>40kg/m2
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Basel, Switzerland

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bigna Buddeberg, Dr. med.

Role: PRINCIPAL_INVESTIGATOR

Department of Anesthesiology, University Hospital Basel

Locations

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Department of Anesthesiology, University Hospital Basel

Basel, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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2020-00774; qu19Buddeberg

Identifier Type: -

Identifier Source: org_study_id

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