Pulmonary Artery Doppler in Preeclamptic Mothers

NCT ID: NCT06755073

Last Updated: 2025-01-01

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 41 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-12-31
• Study Completion Date: 2025-05-31

Brief Summary

Evaluation of Pulmonary artery Doppler parameters in fetuses of mothers with severe preeclampsia

Detailed Description

Preclampsia (PE) represent a major concern in public health, affecting 2-8% of all pregnancies and considered one of the leading causes of perinatal morbidity and mortality. fetal growth restriction (FGR) ia also a common health problem affecting about 5-10% of all pregnancies and commonly associates with preeclampsia . It is estimated that 20% of cases of PE present with FGR and about 50% of early-onset FGR cases will eventually coexist with PE.

Preeclampsia affects about 5% of pregnancies and hypertensive disorders of pregnancy cause over 60,000 maternal fatalities each year around the world .The decision to deliver a woman with severe pre-eclampsia that is far from the term [mid-trimester] is difficult for the obstetrician.In most cases of highly premature pre-eclamptic gestation, certain institutions propose continuing pregnancy until one of the following occurs development of fetal lung maturity, development of fetal or maternal discomfort, or accomplishment of gestational age of 34 to 36-week of gestation .

Numerous tests have been developed in an attempt to identify if fetal lung maturation has reached a level sufficient to prevent the development of fetal RDS. These tests are based on four core themes: biochemical testing for active surfactant components, biophysical testing for surfactant functionality, physical testing of amniotic fluid opacity, and ultrasound examination of the fetuses and their tissues . Neonatal RDS has been predicted using fetal pulmonary artery Doppler. Kim and colleagues discovered that a high PAT/ET was linked to newborn RDS .The development of RDS in preterm newborns is linked to an increased acceleration time to ejection time [AT/ET] ratio in the fetal pulmonary artery .

Conditions

Pulmonary Artery Doppler

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Pulmonary artery Doppler

The four chamber view, outflow tract views, triple vessel view, longitudinal view of the aortic arch and ductal arch, and colour flow mapping will be used for a comprehensive examination to assess structural heart integrity and rule out cardiac defects. Pulmonary artery is detected and power Doppler cursor is put on it just beyond pulmonary valve and indices are calculated.

Pulmonary artery Doppler ultrasound

Intervention Type: RADIATION

Doppler ultrasound of fetal pulmonary artery

Interventions

Pulmonary artery Doppler ultrasound

Doppler ultrasound of fetal pulmonary artery

Intervention Type: RADIATION

Eligibility Criteria

Inclusion Criteria

• preeclampsia patients Pregnant 28 -37 weeks

Exclusion Criteria

• fetal death Congenital fetal anomalies Fetal Cardiac arrhythmia

• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Mohamed Gamal M.fekry

Lecturer obstetric and gynecology, Specialist Urogynecology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Women's Health Hospital

Asyut, , Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

Mohamed Fekry, PhD

Role: CONTACT

mohamedbeethoven2040@gmail.com

0882312388

Facility Contacts

Mohamed Fekry, Lecturer

Role: primary

mohamedbeethoven2040@gmail.com

0882312388

Other Identifiers

PAD

Identifier Type: -

Identifier Source: org_study_id