Evaluation of Fetal Cardiac Function and Vascular Hemodynamics in Intrauterine Growth Restriction

NCT ID: NCT03108040

Last Updated: 2020-02-18

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 534 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-05-10
• Study Completion Date: 2020-01-10

Brief Summary

Intrauterine growth restriction (IUGR) is one of the major contributors to perinatal mortality and morbidity and is characterized by complex hemodynamic changes involving placental and fetal arterial, cardiac and venous circulations .However, the temporal sequence of these modifications in relation to other hemodynamic changes of the fetal arterial and venous circulations is unknown.

The aim of this study was to evaluate cardiac function and other hemodynamic changes in a group of fetuses with IUGR and clinical impact on perinatal outcome .

Conditions

Fetal Hypoxia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

• Singleton fetus with normal fetal anatomy documented a detailed sonogram.
• Fetal abdominal circumference <5th percentile for gestational age.
• Evidence of placental insufficiency documented by an elevated umbilical artery pulsatility index (UA-PI) by reference ranges.

Exclusion Criteria

• evidence of fetal infection
• chorioamnionitis
• fetal anomalies
• abnormal fetal karyotype
• patient withdrawal from the study and/or unavailability for follow-up.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Sief el eslam Ahmed Ali

Principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Advanced Fetal Cair Unit - Assiut University

Asyut, , Egypt

Countries

Egypt

Other Identifiers

AUN80

Identifier Type: -

Identifier Source: org_study_id