Transcranial Doppler Ultrasonography and Brain Death

NCT ID: NCT01070563

Last Updated: 2011-07-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

44 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-02-28

Study Completion Date

2011-06-30

Brief Summary

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In France the diagnosis of brain death relies on electroencephalography (EEG) or cerebral angiography. Concerning the latter a time of 6 hours is mandatory between the clinical diagnosis and the realization of the cerebral computed tomography (CT) angiography. Transcranial doppler (TCD) is not recommended in the french guidelines for the diagnosis of brain death. In other countries, some flow patterns allow to confirm the diagnosis of brain death. The hypothesis of our study is that TCD could shorten the time between the clinical diagnosis of brain death and the realization of the CT angiography.

Detailed Description

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Conditions

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Brain Dead

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Usual

CT angiography is performed 6 hours after the clinical diagnosis of brain death.

No interventions assigned to this group

TCD

When the diagnosis of brain death is made, TCD is performed and then every 2 hours until the flow patterns compatible with brain death are found. Then a CT angiography is performed.

Transcranial doppler

Intervention Type OTHER

A TCD is performed on all cerebral arteries (mean cerebral arteries, anterior cerebral arteries, basilar trunk, vertebral arteries and carotid arteries) until a flow pattern compatible with brain death is found

Interventions

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Transcranial doppler

A TCD is performed on all cerebral arteries (mean cerebral arteries, anterior cerebral arteries, basilar trunk, vertebral arteries and carotid arteries) until a flow pattern compatible with brain death is found

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* brain death patients

Exclusion Criteria

* craniectomy
* post anoxia encephalopathy
* no TCD performed before the clinical diagnosis of brain death
* transtemporal approach impossible
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut d'Anesthesiologie des Alpes Maritimes

OTHER

Sponsor Role lead

Responsible Party

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Nice University Hospital

Principal Investigators

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Jean-Christophe Orban, MD

Role: PRINCIPAL_INVESTIGATOR

Nice University Hospital

Locations

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Centre Hospitalier Universitaire de Nice

Nice, , France

Site Status

Countries

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France

References

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Orban JC, El-Mahjoub A, Rami L, Jambou P, Ichai C. Transcranial Doppler shortens the time between clinical brain death and angiographic confirmation: a randomized trial. Transplantation. 2012 Sep 27;94(6):585-8. doi: 10.1097/TP.0b013e3182612947.

Reference Type DERIVED
PMID: 22918218 (View on PubMed)

Other Identifiers

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IAAM 2010-1

Identifier Type: -

Identifier Source: org_study_id

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