Evaluation of Prognosis Factors of Neurological Evolution in Cardiac Arrest
NCT ID: NCT02849561
Last Updated: 2016-07-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
82 participants
INTERVENTIONAL
2014-01-31
2015-07-31
Brief Summary
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The goal of this study is to evaluate the pupillary light reflex measured by the dimension of the pupil (diameter) as a prognosis factor neurological evolution in post cardiac arrest. By participating to this study, the patient get the same tratments and exams than in a usual managing cares.
In addition of these events, the pupillary light reflex is studied as soon as the patient is accepted in the department, and then on the second day.
Currently, the evaluation of the neurological becoming rely on a multimodal clinical and paraclinical approach.
The study of the pupillary light reflex measured by the diameter of the pupil could be a prognosis factor of neurological evolution for patients in post cardiac arrest, so a reliable and available prognosis marker in patient care.
The goal of this study is to evaluate the pupillary light reflex (RPM), measured by the diameter of the pupil as a prognosis factor of neurological evaluation of admitted patients after a cardiac arrest.
Principal criteria of judgement is the percentage of the pupillary light reflex variation measured with Neurolight®, compared between two groups.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
FACTORIAL
DOUBLE
Study Groups
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Favourable neurological evolution after cardiac arrest
MGOS 4-5
Therapeutic hypothermia
With a mattress at 4°C to reach a central temperature at 33,5°C.
Synchronized Intermittent Mandatory Ventilation
Constant volume 6 ml/kg
Electroencephalography
Pupillary light reflex surveillance
With Neurolight® device.
Transcranial Doppler
Monitoring tool for brain hemodynamic evaluation. With Philips HD15 Ultrasound system®.
Unfavourable neurological evolution after cardiac arrest
MGOS 1-3
Therapeutic hypothermia
With a mattress at 4°C to reach a central temperature at 33,5°C.
Synchronized Intermittent Mandatory Ventilation
Constant volume 6 ml/kg
Electroencephalography
Pupillary light reflex surveillance
With Neurolight® device.
Transcranial Doppler
Monitoring tool for brain hemodynamic evaluation. With Philips HD15 Ultrasound system®.
Interventions
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Therapeutic hypothermia
With a mattress at 4°C to reach a central temperature at 33,5°C.
Synchronized Intermittent Mandatory Ventilation
Constant volume 6 ml/kg
Electroencephalography
Pupillary light reflex surveillance
With Neurolight® device.
Transcranial Doppler
Monitoring tool for brain hemodynamic evaluation. With Philips HD15 Ultrasound system®.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Entry in resuscitation after a cardiac arrest intra or extra-hospital
* Resumption of a spontaneous cardiac activity
* Affiliation to a social security system
Exclusion Criteria
* Age under 18 years
* Pregnant women
* Previous neurological damages
* Persons deprived of liberty by judicial or administrative decision
18 Years
ALL
No
Sponsors
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University Hospital, Grenoble
OTHER
Responsible Party
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Principal Investigators
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Michel Durand, Doctor
Role: PRINCIPAL_INVESTIGATOR
Grenoble Hospital University
Locations
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UniversityHospitalGrenoble
La Tronche, , France
Countries
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References
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Other Identifiers
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38RC13.713
Identifier Type: -
Identifier Source: org_study_id