Transcranial Doppler (TCD) Ultrasound and Cognition in Cerebral Vascular Disease. (SUNRISE)
NCT ID: NCT06735274
Last Updated: 2024-12-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
517 participants
OBSERVATIONAL
2020-10-15
2023-08-30
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Ischemic Stroke (Carotid Circulation)
Patients with ischemic stroke of atherosclerotic, cardioembolic and embolic etiology from an unknown source
Cerebral Autoregulation (CAR)
Cerebral Autoregulation (CAR) is the mechanism capable of maintaining cerebral blood flow constant despite fluctuations in blood pressure. The evaluation of dynamic CAR (dCAR) with spontaneous blood pressure variations allows it to be applied in acute and non-collaborating patients
Neurovascular coupling (NVC)
Neurovascular coupling (NVC) is the relationship between neural activity and cerebral blood flow, allowing this activity to be evaluated in spatiotemporal terms .
Microembolic signals (MES)
Microembolic signals (MES)
Montreal Cognitive Assessment (MoCA)
Montreal Cognitive Assessment (MoCA)
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
Instrumental Activities of Daily Living Scale (IADL)
Instrumental Activities of Daily Living Scale (IADL)
Modified Rankin Scale for Neurologic Disability (mRS)
Modified Rankin Scale for Neurologic Disability (mRS)
Ischemic Stroke (Posterior Circulation)
Patients with ischemic stroke of atherosclerotic, cardioembolic and embolic etiology from an unknown source
Cerebral Autoregulation (CAR)
Cerebral Autoregulation (CAR) is the mechanism capable of maintaining cerebral blood flow constant despite fluctuations in blood pressure. The evaluation of dynamic CAR (dCAR) with spontaneous blood pressure variations allows it to be applied in acute and non-collaborating patients
Neurovascular coupling (NVC)
Neurovascular coupling (NVC) is the relationship between neural activity and cerebral blood flow, allowing this activity to be evaluated in spatiotemporal terms .
Microembolic signals (MES)
Microembolic signals (MES)
Montreal Cognitive Assessment (MoCA)
Montreal Cognitive Assessment (MoCA)
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
Instrumental Activities of Daily Living Scale (IADL)
Instrumental Activities of Daily Living Scale (IADL)
Modified Rankin Scale for Neurologic Disability (mRS)
Modified Rankin Scale for Neurologic Disability (mRS)
Haemorrhagic Stroke
Patients with intracerebral haemorrhages
Cerebral Autoregulation (CAR)
Cerebral Autoregulation (CAR) is the mechanism capable of maintaining cerebral blood flow constant despite fluctuations in blood pressure. The evaluation of dynamic CAR (dCAR) with spontaneous blood pressure variations allows it to be applied in acute and non-collaborating patients
Neurovascular coupling (NVC)
Neurovascular coupling (NVC) is the relationship between neural activity and cerebral blood flow, allowing this activity to be evaluated in spatiotemporal terms .
Microembolic signals (MES)
Microembolic signals (MES)
Montreal Cognitive Assessment (MoCA)
Montreal Cognitive Assessment (MoCA)
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
Instrumental Activities of Daily Living Scale (IADL)
Instrumental Activities of Daily Living Scale (IADL)
Modified Rankin Scale for Neurologic Disability (mRS)
Modified Rankin Scale for Neurologic Disability (mRS)
Interventions
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Cerebral Autoregulation (CAR)
Cerebral Autoregulation (CAR) is the mechanism capable of maintaining cerebral blood flow constant despite fluctuations in blood pressure. The evaluation of dynamic CAR (dCAR) with spontaneous blood pressure variations allows it to be applied in acute and non-collaborating patients
Neurovascular coupling (NVC)
Neurovascular coupling (NVC) is the relationship between neural activity and cerebral blood flow, allowing this activity to be evaluated in spatiotemporal terms .
Microembolic signals (MES)
Microembolic signals (MES)
Montreal Cognitive Assessment (MoCA)
Montreal Cognitive Assessment (MoCA)
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
Instrumental Activities of Daily Living Scale (IADL)
Instrumental Activities of Daily Living Scale (IADL)
Modified Rankin Scale for Neurologic Disability (mRS)
Modified Rankin Scale for Neurologic Disability (mRS)
Eligibility Criteria
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Inclusion Criteria
* Patients with intracerebral haemorrhages; Patients with ischemic stroke of atherosclerotic, cardioembolic and embolic etiology from an unknown source;
* Previous mRS equal or more than 4;
* National Institutes of Health Stroke Scale (NIHSS)≤20 at admission;
* IQCODE final score\<3.0
Exclusion Criteria
* Absence of adequate temporal bone window for Transcranial Doppler monitoring;
* Patients with a large cerebral infarct (greater than on third of the middle cerebral artery territory) or a strategic infarct (paramedian thalamus, medial frontal cortex, or hippocampus) evaluated in the 24 hours-CT;
* Average life expectancy less than 1 year for a different cause of cardiovascular disease;
* Patients with intracranial vascular malformation, intracranial venous thrombosis, head trauma or tumour and haemorrhagic transformation within an infarct;
* Serious kidney and systemic diseases;
* Active cancer patients;
18 Years
ALL
No
Sponsors
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Hospital de Sao Joao, Porto
UNKNOWN
RISE Study Group
NETWORK
Universidade do Porto
OTHER
Responsible Party
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Principal Investigators
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Pedro Castro, PhD
Role: PRINCIPAL_INVESTIGATOR
Universidade do Porto
Locations
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Centro Hospitalar e Universitário de São João, EPE
Porto, , Portugal
Countries
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Other Identifiers
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SUNRISE
Identifier Type: -
Identifier Source: org_study_id