Reducing Risk of Stroke and DementIa In patientS With COVert cERebrovascular Disease

NCT ID: NCT06878430

Last Updated: 2025-08-11

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-12-31
• Study Completion Date: 2027-06-30

Brief Summary

The purpose of the DISCOVER study is to pilot acceptable approaches to people with covert cerebrovascular disease (CCD) and their follow-up. This is the first step in designing efficient randomised trials of treatments to reduce the risk of stroke or dementia in people with CCD.

Detailed Description

DISCOVER is a prospective cohort involving individuals with covert cerebrovascular disease (CCD) in NHS Lothian. Participants will be recruited through electronic health records and clinician collaborators. Participants will be monitored at 3 and 6 months and where possible 12 months to assess cognitive, functional, and vascular event outcomes.

Conditions

Covert Cerebrovascular Disease

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

Functional and Cognitive scores

We will collect information about prior neurological symptoms, including prior symptoms suggestive of TIA or stroke, cognitive or motor symptoms, blood pressure and other known vascular risk factors, medicines, frailty, functional status, education, and employment status We will collect a baseline validated function and cognitive score, and take a sample of speech. Speech will be measured at assessment, in collaboration with the NeuroCARE Clinical and Digital Measures Module (22/SS/0010 IRAS No. 310885).

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• People who, at the time the letter is prepared or are identified by a clinician

• Age ≥ 65 years
• Have no known history of:

• Stroke or TIA
• Dementia
• Parkinson's disease
• Multiple sclerosis
• Metastatic cancer (or non-meningioma brain tumour).
• A CT or MRI scan report ≤5 years before study start date with of one or more of:

• Cerebral small vessel disease
• Deep old ischaemic stroke
• Cortical old ischaemic stroke

Exclusion Criteria

• Text of brain scan report unreadable
• Do not consent to take part in study procedures
• Unable to consent
• Unable to communicate by email, letter or telephone through language, speech disability or lack of address
• Unlikely to survive one year past enrolment in judgement of the study investigator

• Minimum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

NHS Lothian

OTHER_GOV

Sponsor Role: collaborator

University of Edinburgh

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Central Contacts

William Whiteley

Role: CONTACT

william.whiteley@ed.ac.uk

+44(131) 4659602

Other Identifiers

HIPS/23/02

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

AC25041

Identifier Type: -

Identifier Source: org_study_id