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Ventilatory Constraint, Breathing Pattern and Ventilatory Responses in Obese Postmenopausal Women

NCT ID: NCT01034098

Last Updated: 2009-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-12-31

Study Completion Date

2007-04-30

Brief Summary

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The purpose of this study was to examine the dynamic lung volumes in obese post-menopausal women (without hormone replacement therapy) during exercise and their correlations with dyspnea.

Detailed Description

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Obesity-related changes in lung volumes have shown to affect breathing mechanisms. During exercise, altered breathing mechanisms increase potential for expiratory flow limitation and compromise exercise capacity. Estrogen and progesterone are potent respiratory stimulants, and their effects in the physiologic regulation of breathing are down-regulated after menopause. Therefore, we theorized that the combined obesity and reduced sex hormone levels after menopause work as a double jeopardy to cause mechanical ventilatory constraint which aggravates dyspnea sensation during exercise, and thus a reduction in exercise capacity. The purpose of this study was to exam the dynamic lung volumes in obese post-menopausal women (without hormone replacement therapy) during exercise and their correlations with dyspnea.

From doctoral referral and advertisement, 24 obese (BMI ≧ 27 kg/m2) and 26 lean post-menopausal women were recruited for the study. Pulmonary function and body composition were measured at rest. A maximal flow volume loop (MFVL) was obtained at baseline. All subjects then performed an incremental exercise test on a cycle ergometer with workload increasing 25 watts every 3 min. During exercise, at each workload, the tidal exercise FV loops were obtained and an inspiratory capacity (IC) maneuver was conducted to assess changes in end-expiratory lung volume (EELV) and end inspiratory lung volume (EILV). Dyspnea and leg fatigue were assessed using the Borg scale. Analysis of variance with repeated measurements was used to test the significance of the mean differences between the two groups during exercise. Linear regression analysis was used to determine whether changes in dynamic lung volumes during exercise were related to changes in Borg scores. Statistical significance was established at p\<0.05.

Conditions

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Obesity Postmenopausal Women

Keywords

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Obesity Postmenopausal women Mechanical ventilatory constraints Dynamic lung volume Expiratory flow limitation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Post-menopausal women

Post-menopausal women (without hormone replacement therapy)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Postmenopausal women (for at least 1 year)
* Age below 69 y/o
* Not receiving hormone replacement therapy

Exclusion Criteria

* Cardiopulmonary disease
* Musculoskeletal disease affecting results of maximal exercise test
Minimum Eligible Age

50 Years

Maximum Eligible Age

69 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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School and Graduate Institute of Physical Therapy, National Taiwan University

Principal Investigators

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Li-Ying Wang, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

School and Graduate Institute of Physical Therapy, National Taiwan University

Locations

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School and Graduate Institute of Physical Therapy, National Taiwan University

Taipei, , Taiwan

Site Status

Countries

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Taiwan

Other Identifiers

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9461701144

Identifier Type: -

Identifier Source: org_study_id