Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1224 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-01-31

Study Completion Date

2009-11-30

Brief Summary

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A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.

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Detailed Description

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Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.

Conditions

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Single-nucleotide Polymorphism (SNP) for Glaucoma

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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POAG group

Elevated intraocular pressure normal open angle glaucomatous optic nerve head abnormality glaucomatous visual field defect

SNP analysis of the DNA

Intervention Type GENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Normal control

Normal intraocular pressure No optic disc abnormality No visual field defect No significant ocular and systemic disease

SNP analysis of the DNA

Intervention Type GENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Interventions

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SNP analysis of the DNA

SNP analysis of the DNA obtained from peripheral blood sample

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of primary open angle glaucoma

Exclusion Criteria

* Primary open angle glaucoma combined with congenital ocular disease
* Primary open angel glaucoma combined with other ocular disease
* Significant systemic disease other than systemic hypertension and diabetes

Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes