How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

97 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-03-31

Study Completion Date

2009-08-31

Brief Summary

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Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases. So far, research has only been able to find the genes responsible for glaucoma in a small percentage of people who have glaucoma. The purpose of this project is to study the genes in patients with and without glaucoma to find additional genes that may be responsible for causing glaucoma.

Detailed Description

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Four tubes of blood will be taken from 100 people. Of those, half will have primary open angle glaucoma (POAG) and the other half will be controls (normals), half will be caucasians and the other half will be african americans, half male and half female. All groups will have a routine ophthalmic eye exam, color vision, snellen vision, and visual field done.

Conditions

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Primary Open Angle Glaucoma

Keywords

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primary open angle glaucoma Nuclear Genetics Mitochondrial DNA POAG

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Primary Open Angle Glaucoma (POAG)

No interventions assigned to this group

2

Controls (Normals, patients without glaucoma)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* 40 yrs
* Caucasian or African American
* Male or female with POAG, PACG, PXFG,
* Normal

Exclusion Criteria

* Other ophthamic co-morbidities
* Other ethnic groups
* Unable to understand and give informed consent

Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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George L. Spaeth MD

Director Glaucoma Research Center Wills Eye; Director Medical Research and Education Glaucoma Service Foundation Wills Eye; Esposito Research Professor, Thomas Jefferson University

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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George L Spaeth, MD

Role: PRINCIPAL_INVESTIGATOR

Wills Eye Institute

Locations

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Wills Eye Glaucoma Service

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

References

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Abu-Amero KK, Azad TA, Spaeth GL, Myers J, Katz LJ, Moster M, Bosley TM. Unaltered myocilin expression in the blood of primary open angle glaucoma patients. Mol Vis. 2012;18:1004-9. Epub 2012 Apr 21.

Reference Type RESULT

PMID: 22550394 (View on PubMed)

Abu-Amero KK, Azad TA, Spaeth GL, Myers J, Katz LJ, Moster M, Bosley TM. Absence of altered expression of optineurin in primary open angle glaucoma patients. Mol Vis. 2012;18:1421-7. Epub 2012 Jun 1.