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Prevalence of Corneal Astigmatism Before Glaucoma Surgery in Chinese Patients With Primary Angle-closure Glaucoma

NCT ID: NCT03159780

Last Updated: 2017-10-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

808 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-01

Study Completion Date

2017-08-31

Brief Summary

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Clear-lens extraction has been considered as first-line therapy for primary angle closure glaucoma(PACG) and application of toric intraocular lens (IOLs) leads to better postoperative visual acuity, yet little is known about the prevalence of corneal astigmatism in PACG patients. We intend to make biometry examination for Chinese PACG patients, to obtain keratometry (K) , axial length (AL) and so on, and demographics data will also be recorded. We will study the prevalence of corneal astigmatism before glaucoma surgery in Chinese patients with PACG. Furthermore, differences of corneal astigmatism between primary angle-closure glaucoma and cataract patients will be explored. Finally, the prevalence of corneal astigmatism before glaucoma surgery in Chinese patients with PACG will be portrayed and can be instructive to the IOLs' manufactering.

Detailed Description

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Biometry examination contains keratometry (K) , axial length (AL), central anterior chamber depth, visual field loss(mean deviation, MD), choroidal thickness(CT), range of goniosynechia, and stage of PACG.

Demographics data contains age, gender, and eye.

Conditions

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Glaucoma, Angle-Closure Astigmatism

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Patients who are phakic and aged 40 years or older , and had newly diagnosed primary angle closure with intraocular pressure 30 mm Hg or greater or primary angle-closure glaucoma, will be recruited during preoperative screening at Zhongshan Ophthalmic Center.

Exclusion Criteria

* Patients with corneal disease, irregular astigmatism, previous corneal or intraocular surgery, or a history of ocular inflammation will be excluded.
Minimum Eligible Age

40 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mingkai Lin

OTHER

Sponsor Role lead

Responsible Party

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Mingkai Lin

Head of Glaucoma Center

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Mingkai Lin, MD

Role: PRINCIPAL_INVESTIGATOR

Zhongshan Ophthalmic Center, Sun Yat-sen University

Locations

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Zhongshan Ophthalmic Center

Guangzhou, Guangdong, China

Site Status

Countries

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China

References

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Azuara-Blanco A, Burr J, Ramsay C, Cooper D, Foster PJ, Friedman DS, Scotland G, Javanbakht M, Cochrane C, Norrie J; EAGLE study group. Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised controlled trial. Lancet. 2016 Oct 1;388(10052):1389-1397. doi: 10.1016/S0140-6736(16)30956-4.

Reference Type RESULT
PMID: 27707497 (View on PubMed)

Gao X, Huang W, Wang W, Zhou M, Wang J, Du S, Chen S, Zhang X. Topographic profile of choroid in eyes after acute primary angle-closure. Can J Ophthalmol. 2016 Oct;51(5):354-361. doi: 10.1016/j.jcjo.2016.02.025. Epub 2016 Sep 3.

Reference Type RESULT
PMID: 27769326 (View on PubMed)

Chen W, Zuo C, Chen C, Su J, Luo L, Congdon N, Liu Y. Prevalence of corneal astigmatism before cataract surgery in Chinese patients. J Cataract Refract Surg. 2013 Feb;39(2):188-92. doi: 10.1016/j.jcrs.2012.08.060. Epub 2012 Nov 7.

Reference Type RESULT
PMID: 23141077 (View on PubMed)

Zuo C, Gong R, Chen W, Chen C, Su J, Wei K, Gao X, Lin M, Ge J. Investigation of Corneal Astigmatism in Chinese Patients With Primary Angle Closure Disease. J Glaucoma. 2018 Dec;27(12):1131-1135. doi: 10.1097/IJG.0000000000001061.

Reference Type DERIVED
PMID: 30134368 (View on PubMed)

Other Identifiers

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ZhongshanOC20170503

Identifier Type: -

Identifier Source: org_study_id