Macular Pigment Optical Density in Primary Angle-closure Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-11-11

Study Completion Date

2024-12-30

Brief Summary

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Glaucoma is the leading cause of irreversible blindness in the world, and primary angle-closure glaucoma (PACG) is the most important type of glaucoma in Asia. Primary angle closure disease (PACD) is a group of diseases related to PACG, and the pathogenesis is still unclear. Macular pigment has the functions of filtering short-wavelength waves and anti-oxidation, which are related to visual function. Previous studies have found that the macular pigment density (MPOD) is significantly reduced in primary open-angle glaucoma. This project uses the single-wavelength reflection method to measure MPOD, observes the characteristics of PACD and the normal control group's changes in retinal MPOD, and explains the relationship between PACD's MPOD changes and angle-closure glaucoma optic nerve damage

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Detailed Description

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Observation index： Visual acuity，Intraocular pressure，Ophthalmoscope，MPOD，Visual field and OCT.

Inspection parameters of OCT：

1. Retinal nerve fiber layer thickness
2. Ganglion cell complex thickness
3. Mean thickness of the central retina
4. Mean defect

Conditions

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Glaucoma Glaucoma, Angle-Closure Macular Pigment Optical Density

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Primary Angle Clousure Diseases Eyes

Over 40 years old, regardless of gender. Patients diagnosed with PACD (PACG or PAC or PACS) with phakic eyes. Peripheral iridectomy or trabeculectomy, more than 3 months after operation.

Ocular examination

Intervention Type OTHER

All participants underwent a detailed examination, including visual acuity, slit lamp biomicroscopy, direct ophthalmoscopy, optometry noncontact tonometry,MPOD measurement and optical coherence tomography (OCT) measurement

Matched Eyes

Healthy population matched by sex and age.

Ocular examination

Intervention Type OTHER

All participants underwent a detailed examination, including visual acuity, slit lamp biomicroscopy, direct ophthalmoscopy, optometry noncontact tonometry,MPOD measurement and optical coherence tomography (OCT) measurement

Interventions

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Ocular examination

All participants underwent a detailed examination, including visual acuity, slit lamp biomicroscopy, direct ophthalmoscopy, optometry noncontact tonometry,MPOD measurement and optical coherence tomography (OCT) measurement

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Experimental group：
* (1) According to the diagnostic criteria of PACD
* (2)History of peripheral iridectomy or trabeculectomy
* (3)Over 40
* (4)Phakic eyes
* (5)Intraocular pressure is less than 21mmhg, more than one week
* (6)Eyes with clear optical media.
* Control group：
* (1)No history of glaucoma and other eye diseases
* (2)Phakic eyes
* (3)Over 40
* (4)Intraocular pressure10\~21mmHg

Exclusion Criteria

* (1)History of corneal diseases
* (2)History of eye tumor or other ophthalmic surgery
* (3)Cataract
* (4)Taking supplements containing lutein within 6 months
* (5)Snellen's visual acuity was less than 6 / 20，the diopter is beyond ± 6 degrees

Minimum Eligible Age

40 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes