Correlation Between Optical Coherence Tomography Angiography and Photopic Negative Response in Patients With Glaucoma
NCT ID: NCT05104294
Last Updated: 2021-11-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
76 participants
OBSERVATIONAL
2020-02-02
2020-08-15
Brief Summary
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Detailed Description
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OCT Angiography (OCTA) is a promising tool for diagnosing and monitoring glaucomatous patients. It can evaluate glaucomatous damage and assess the ganglion cells' health by measuring blood flow within the optic nerve and the retina Correlation between vascular , structural and functional changes of the peripapillary retinal nerve fiber (RNFL) and macular/ganglion cell complex (GCC) can lead to early detection of glaucomatous changes.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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mild Primary Open Angle Glaucoma group (Group I)
28 eyes of 16 patients with mild primary open angle glaucoma as group I.
Optical Coherence Tomography- Angiography
Peripapillary retinal nerve fiber layer thickness, ganglion cell complex, superficial and deep capillary plexus vessel density were measured.
Photopic negative response
Both the implicit time and amplitude of PhNR were recorded.
moderate to severe Primary Open Angle Glaucoma group (Group II)
44 eyes of 24 patients with moderate to severe primary open angle glaucoma as group II.
Optical Coherence Tomography- Angiography
Peripapillary retinal nerve fiber layer thickness, ganglion cell complex, superficial and deep capillary plexus vessel density were measured.
Photopic negative response
Both the implicit time and amplitude of PhNR were recorded.
Control Group
80 eyes of 40 healthy subjects as control group.
Optical Coherence Tomography- Angiography
Peripapillary retinal nerve fiber layer thickness, ganglion cell complex, superficial and deep capillary plexus vessel density were measured.
Photopic negative response
Both the implicit time and amplitude of PhNR were recorded.
Interventions
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Optical Coherence Tomography- Angiography
Peripapillary retinal nerve fiber layer thickness, ganglion cell complex, superficial and deep capillary plexus vessel density were measured.
Photopic negative response
Both the implicit time and amplitude of PhNR were recorded.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Spherical equivalent (SE) between -2 and +2 D.
* No history of previous eye surgery, trauma, or systemic diseases.
Exclusion Criteria
* Media opacity as (cataract or corneal scar).
* Any history of ocular surgeries or trauma.
* Optic nerve anomaly or other retinal diseases.
* Unreliable visual field tests (33% fixation losses, false positive, and false- negative results).
35 Years
55 Years
ALL
Yes
Sponsors
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Benha University
OTHER
Responsible Party
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Ahmed Abdelshafy
Lecturer of Ophthalmology
Principal Investigators
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Marwa A Tabl, MD
Role: STUDY_CHAIR
Benha University
Locations
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Benha University
Banhā, Benha, Egypt
Countries
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References
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Tabl AA, Tabl MA. Correlation between OCT-angiography and photopic negative response in patients with primary open angle glaucoma. Int Ophthalmol. 2023 Jun;43(6):1889-1901. doi: 10.1007/s10792-022-02588-9. Epub 2022 Nov 28.
Other Identifiers
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RC-9-11-01
Identifier Type: -
Identifier Source: org_study_id