A Phase II Dose Response Study in Japan in Chronic Hepatitis B

NCT ID: NCT01022801

Last Updated: 2010-02-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-08-31

Study Completion Date

2005-03-31

Brief Summary

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To demonstrate the dose response of entecavir in Japanese patients as measured by HBV DNA levels by PCR (log10 copies/mL) at Week 22

Detailed Description

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Conditions

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Chronic Hepatitis B

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Entecavir (0.01 mg)

Group Type EXPERIMENTAL

Entecavir

Intervention Type DRUG

Capsule, P.O., 0.01, 0.1 or 0.5 mg, once daily for 24 weeks

Entecavir (0.1 mg)

Group Type EXPERIMENTAL

Entecavir

Intervention Type DRUG

Capsule, P.O., 0.01, 0.1 or 0.5 mg, once daily for 24 weeks

Entecavir (0.5 mg)

Group Type EXPERIMENTAL

Entecavir

Intervention Type DRUG

Capsule, P.O., 0.01, 0.1 or 0.5 mg, once daily for 24 weeks

Interventions

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Entecavir

Capsule, P.O., 0.01, 0.1 or 0.5 mg, once daily for 24 weeks

Intervention Type DRUG

Other Intervention Names

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Baraclude BMS-200475

Eligibility Criteria

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Inclusion Criteria

* Positive for HBsAg OR, negative for IgM core antibody and confirmation of chronic hepatitis B on liver biopsy,
* Positive for HBeAg OR negative for HBeAg with positive HBeAb,
* Documented HBV Viremia on 2 or more occasions: Viremia on sample drawn AND HBV DNA of ≥ 40 MEq/mL by Quantiplex assay at the screening visit
Minimum Eligible Age

20 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Bristol-Myers Squibb

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Related Links

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Other Identifiers

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AI463-047

Identifier Type: -

Identifier Source: org_study_id

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