Promote Q Cardiac Resynchronization Therapy Defibrillator (CRT-D) and Quartet Left Ventricular Heart Lead Study

NCT ID: NCT00990665

Last Updated: 2019-02-27

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

178 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2012-07-31

Brief Summary

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The objective of this study is to assess the safety and efficacy of the Quartet™ lead and Promote Q® device system in a patient population indicated for cardiac resynchronization therapy.

Detailed Description

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Conditions

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Heart Failure

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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CRT-D and LV lead

Group Type EXPERIMENTAL

CRT-D and LV lead (Quartet™ lead and Promote Q® device system)

Intervention Type DEVICE

Promote Q CRT-D and Quartet LV lead

Interventions

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CRT-D and LV lead (Quartet™ lead and Promote Q® device system)

Promote Q CRT-D and Quartet LV lead

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Approved indication per ACC/AHA/HRS guidelines for implantation of a CRT-D system for treatment of heart failure or lifethreatening ventricular tachyarrhythmia(s)
* Receiving a new implant or undergoing an upgrade from an existing ICD or pacemaker implant with no prior LV lead placement.
* Ability to provide informed consent for study participation and is willing and able to comply with the prescribed follow-up tests and schedule of evaluations

Exclusion Criteria

* Have had a recent CVA or TIA within three months of enrollment
* Have a contraindication for an emergency thoracotomy
* Have a hypersensitivity to a single 1.0mg dose of dexamethasone sodium phosphate or short term contact with heparin
* Have a classification of Status 1 for cardiac transplantation or consideration for transplantation over the next 3 months
* Have undergone a cardiac transplantation within 40 days of enrollment
* Have had a recent myocardial infarction, unstable angina or cardiac revascularization (PTCA, Stent or CABG) within 40 days of enrollment
* Are currently participating in a clinical investigation that includes an active treatment arm
* Are pregnant or planning to become pregnant during the duration of the study
* Have a life expectancy of less than 6 months due to any condition
* Are less than 18 years of age
* Are unable to comply with the follow up schedule
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gery Tomassoni, MD

Role: STUDY_CHAIR

Central Baptist Hospital

Locations

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University Hospital of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

Baptist Health Medical Center

Little Rock, Arkansas, United States

Site Status

Arkansas Heart Hospital

Little Rock, Arkansas, United States

Site Status

Glendale Memorial Medical Center

Glendale, California, United States

Site Status

University of Southern California

Los Angeles, California, United States

Site Status

ACS Research Group

Mountain View, California, United States

Site Status

Regional Cardiology Associates

Sacramento, California, United States

Site Status

Scripps Green Hospital

San Diego, California, United States

Site Status

Orlando Heart Center

Orlando, Florida, United States

Site Status

The Heart and Vascular Institute of Florida - S. Pinellas

St. Petersburg, Florida, United States

Site Status

Piedmont Hospital

Atlanta, Georgia, United States

Site Status

Midwest Heart Foundation

Lombard, Illinois, United States

Site Status

Central Baptist Hospital

Lexington, Kentucky, United States

Site Status

Lahey Clinical Medical Center

Burlington, Massachusetts, United States

Site Status

Thoracic Cardiovascular Healthcare Foundation

Lansing, Michigan, United States

Site Status

Deborah Heart and Lung Center

Browns Mills, New Jersey, United States

Site Status

Morristown Memorial Hospital

Morristown, New Jersey, United States

Site Status

Mount Sinai Hospital

New York, New York, United States

Site Status

The Cleveland Clinic Foundation

Cleveland, Ohio, United States

Site Status

EMH Regional Medical Center

Elyria, Ohio, United States

Site Status

Lancaster Heart Foundation

Lancaster, Pennsylvania, United States

Site Status

Methodist University Hospital

Memphis, Tennessee, United States

Site Status

St. Thomas Hospital

Nashville, Tennessee, United States

Site Status

Arrhythmia Center for Southern Wisconsin

Milwaukee, Wisconsin, United States

Site Status

Countries

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United States

References

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Tomassoni G, Baker J, Corbisiero R, Love C, Martin D, Niazi I, Sheppard R, Worley S, Beau S, Greer GS, Aryana A, Cao M, Harbert N, Zhang S; Promote(R) Q CRT-D and Quartet(R) Left Ventricular Heart Lead Study Group. Postoperative performance of the Quartet(R) left ventricular heart lead. J Cardiovasc Electrophysiol. 2013 Apr;24(4):449-56. doi: 10.1111/jce.12065. Epub 2013 Jan 22.

Reference Type RESULT
PMID: 23339555 (View on PubMed)

Other Identifiers

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60024498/E

Identifier Type: -

Identifier Source: org_study_id

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