More Options Available With a Quadripolar LV Lead pRovidE In-clinic Solutions to CRT Challenges

NCT ID: NCT01510652

Last Updated: 2019-02-15

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

1078 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-11-30

Study Completion Date

2014-05-31

Brief Summary

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This investigation is designed with the hypothesis that using a quadripolar left ventricular lead results in less interventions when dealing with high pacing thresholds and Phrenic Nerve Stimulation (PNS), both at implant and during follow-up, compared to standard bipolar left ventricular leads.

Detailed Description

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Conditions

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Postoperative Cardiac Complication Heart Failure Left Ventricular Cardiac Dysfunction Inappropriate Phrenic Nerve Stimulation Perioperative/Postoperative Complications

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Quad Group

Patients in the Quad group will be implanted with St. Jude Medical (SJM) quadripolar Left Ventricular (LV) lead Quartet

Group Type ACTIVE_COMPARATOR

Quad Group

Intervention Type DEVICE

Implantation of quadripolar Left ventricular (LV) lead Quartet

BiP Group

Patients in the BiP Group will be implanted with a standard (regulatory approved and commercially available) bipolar left ventricular lead from other companies (non St. Jude Medical leads)

Group Type ACTIVE_COMPARATOR

BiP Group

Intervention Type PROCEDURE

Implantation of standard Left Ventricular (LV) lead

Interventions

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BiP Group

Implantation of standard Left Ventricular (LV) lead

Intervention Type PROCEDURE

Quad Group

Implantation of quadripolar Left ventricular (LV) lead Quartet

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients are indicated for Cardiac Resynchronization Therapy with Defibrillation backup device (CRT-D) implantation, as per current international certified guidelines
* Patients age is 18 years or greater
* Patients must indicate their understanding of the study and willingness to participate by signing the appropriate informed consent form
* Patients must be willing and able to comply with all study requirements

Exclusion Criteria

* Patients with a life expectancy \<12 months.
* Patients who are or may potentially be pregnant.
* Patient has suffered any of the following in the 4 weeks prior to enrolment:

* Myocardial Infarction (MI)
* Coronary Artery Bypass Graft (CABG)
* Unstable Angina Pectoris
* Patient has primary valvular disease which has not been corrected
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Giuseppe Boriani, Pro.

Role: PRINCIPAL_INVESTIGATOR

Policlinico Universitario S. Orsola e Malpighi, Bologna, Italy

Locations

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Ziekenhuis Oost-Limburg

Genk, , Belgium

Site Status

Hopital La Citadelle

Liège, , Belgium

Site Status

Foothills Medical Center

Calgary, , Canada

Site Status

Royal Alexandra Hospital

Edmonton, , Canada

Site Status

QE II Health Sciences

Halifax, , Canada

Site Status

Institut de Cardiologie du Quebec - Hopital Laval

Québec, , Canada

Site Status

HSC Heastern Health

St. Johns, , Canada

Site Status

Paijat-Hame Central Hospital

Lahti, , Finland

Site Status

Tampere University Hospital

Tampere, , Finland

Site Status

CHU La Cavale Blanche

Brest, , France

Site Status

CHU Gabriel Montpied

Clermont-Ferrand, , France

Site Status

CHRU Hopital Albert Michallon

Grenoble, , France

Site Status

Hopital Cardiovasculaire et Pneumologique Louis Pradel

Lyon, , France

Site Status

Hopital de la Timone

Marseille, , France

Site Status

Hopital du Nord - CH Bourrely St. Antoine

Marseille, , France

Site Status

CHU Hopital G&R Laennec

Nantes, , France

Site Status

Nouvelles Cliniques Nantaises

Nantes, , France

Site Status

CHRU Hopital de Pontchaillou

Rennes, , France

Site Status

CHRU Hopital Charles Nicolle

Rouen, , France

Site Status

CHU St. Etienne

Saint-Priest-en-Jarez, , France

Site Status

Clinique du Tonkin

Villeurbanne, , France

Site Status

Charite Campus Virchow Klinikum

Berlin, , Germany

Site Status

Unfallkrankenhaus Berlin-Marzahn

Berlin, , Germany

Site Status

Stadtische Kliniken Bielefeld

Bielefeld, , Germany

Site Status

Klinikum Coburg

Coburg, , Germany

Site Status

Elisabeth-Krankenhaus

Essen, , Germany

Site Status

Universitatsklinikum Greifswald

Greifswald, , Germany

Site Status

Universitatskliniken des Saarlandes

Homburg, , Germany

Site Status

Universitatsklinikum Leipzig

Leipzig, , Germany

Site Status

Stadtisches Klinikum Ludwigshafen

Ludwigshafen, , Germany

Site Status

Klinikum Ludenscheid

Lüdenscheid, , Germany

Site Status

Krankenhaus der Barmherzigen

Trier, , Germany

Site Status

All India Institute of Medical Sciences

New Delhi, , India

Site Status

Escorts Heart Institute and Research Center

New Delhi, , India

Site Status

Barzilai Medical Center

Ashkelon, , Israel

Site Status

Soroka University Hospital

Beersheba, , Israel

Site Status

Kaplan Medical Center

Rehovot, , Israel

Site Status

Sheba Medical Center

Tel Litwinsky, , Israel

Site Status

Policlinico S. Orsola & Malpighi

Bologna, , Italy

Site Status

Azienda Ospedaliera S.Anna e S.Sebastiano

Caserta, , Italy

Site Status

Azienda Ospedaliera Mater Domini

Catanzaro, , Italy

Site Status

Ospedale Vito Fazzi

Lecce, , Italy

Site Status

Ospedale Maggiore della Carità

Novara, , Italy

Site Status

Policlinico Casilino

Rome, , Italy

Site Status

Ospedale SS. Annunziata

Taranto, , Italy

Site Status

Azienda Sanitaria Ospedaliera Molinette S. Giovanni Battista

Torino, , Italy

Site Status

Ospedale Civile Maggiore Verona Borgo Trento

Verona, , Italy

Site Status

Amphia Hospital

Breda, , Netherlands

Site Status

Medisch Spectrum Twente

Enschede, , Netherlands

Site Status

Haga Ziekenhuis

The Hague, , Netherlands

Site Status

MC Haaglanden

The Hague, , Netherlands

Site Status

Slaskie Centrum Chorob Serca

Zabrze, , Poland

Site Status

Hospital de Basurto

Bilbao, , Spain

Site Status

Hospital Ramon y Cajal

Madrid, , Spain

Site Status

Hospital Universitari La Fe

Valencia, , Spain

Site Status

Basel University Hospital

Basel, , Switzerland

Site Status

Hopital Cantonal Universitaire de Geneva

Geneva, , Switzerland

Site Status

Fondazione Cardiocentro Ticino

Lugano, , Switzerland

Site Status

Universitaets Spital Zuerich

Zurich, , Switzerland

Site Status

Queen Elizabeth Hospital

Birmingham, , United Kingdom

Site Status

Royal Bournemouth Hospital

Bournemouth, , United Kingdom

Site Status

University Hospital of Wales

Cardiff, , United Kingdom

Site Status

St. Thomas Hospital

London, , United Kingdom

Site Status

James Cook University Hospital

Middlesbrough, , United Kingdom

Site Status

Countries

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Belgium Canada Finland France Germany India Israel Italy Netherlands Poland Spain Switzerland United Kingdom

References

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Boriani G, Connors S, Kalarus Z, Lemke B, Mullens W, Osca Asensi J, Raatikainen P, Gazzola C, Farazi TG, Leclercq C. Cardiac Resynchronization Therapy With a Quadripolar Electrode Lead Decreases Complications at 6 Months: Results of the MORE-CRT Randomized Trial. JACC Clin Electrophysiol. 2016 Apr;2(2):212-220. doi: 10.1016/j.jacep.2015.10.004. Epub 2015 Nov 11.

Reference Type DERIVED
PMID: 29766873 (View on PubMed)

Other Identifiers

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CR-11-006-HF-ID

Identifier Type: -

Identifier Source: org_study_id

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