S-100B and Neuron-specific Enolase (NSE) in Spinal Trauma

NCT ID: NCT00980434

Last Updated: 2012-04-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-02-29

Study Completion Date

2011-12-31

Brief Summary

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The investigators are studying the clinical worth of the serum markers S-100B and NSE in patients with spinal cord injuries e.g. in patients with vertebral fractures. If there is a injury to the neuronal structures these two proteins could be secreted into the serum and add evidence to the severity of the injury.

Detailed Description

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Conditions

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Spinal Cord Injury

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

patients with neurological symptoms

No interventions assigned to this group

2

patients without neurological symptoms

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* vertebral fracture
* injuries to the vertebral spine

Exclusion Criteria

* head trauma
* polytrauma
Minimum Eligible Age

1 Year

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medical University of Vienna

OTHER

Sponsor Role lead

Responsible Party

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Department for Trauma Surgery

Principal Investigators

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Vilmos Vecsei, M.D. Professor

Role: STUDY_CHAIR

Head of Department

Locations

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Medical University of Vienna

Vienna, Vienna, Austria

Site Status

Countries

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Austria

References

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Loy DN, Kim JH, Xie M, Schmidt RE, Trinkaus K, Song SK. Diffusion tensor imaging predicts hyperacute spinal cord injury severity. J Neurotrauma. 2007 Jun;24(6):979-90. doi: 10.1089/neu.2006.0253.

Reference Type BACKGROUND
PMID: 17600514 (View on PubMed)

Marquardt G, Setzer M, Seifert V. Serum biomarkers for experimental acute spinal cord injury: rapid elevation of neuron-specific enolase and S-100 beta. Neurosurgery. 2006 Mar;58(3):E590; author reply E590. doi: 10.1227/01.NEU.0000207967.91316.8D. No abstract available.

Reference Type BACKGROUND
PMID: 16528168 (View on PubMed)

Marquardt G, Setzer M, Seifert V. Protein S-100b for individual prediction of functional outcome in spinal epidural empyema. Spine (Phila Pa 1976). 2004 Jan 1;29(1):59-62. doi: 10.1097/01.BRS.0000103661.78939.02.

Reference Type BACKGROUND
PMID: 14699277 (View on PubMed)

Marquardt G, Setzer M, Seifert V. Protein S-100b as serum marker for prediction of functional outcome in metastatic spinal cord compression. Acta Neurochir (Wien). 2004 May;146(5):449-52. doi: 10.1007/s00701-004-0242-3. Epub 2004 Mar 22.

Reference Type BACKGROUND
PMID: 15118880 (View on PubMed)

Other Identifiers

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Wolf-4

Identifier Type: -

Identifier Source: org_study_id

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