Pain Phenotyping in Patients With Neuropathic Pain After Spinal Cord Injury
NCT ID: NCT06443281
Last Updated: 2025-12-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
300 participants
OBSERVATIONAL
2024-04-17
2030-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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Patients with spinal cord injury with neuropathic pain
Neurophysiology
Pain-related evoked potentials and nerve conduction studies
Cardiovascular test
Blood pressure control, orthostatic intolerance test, baro-reflex sensitivity, heart-rate variability
Experimental pain paradigms
Temporal summation of pain, conditioned pain modulation
Quantitative sensory testing
Thermal and mechanical sensory testing
Clinical pain phenotype
Pain drawings, plus and minus signs of pain
Patients with spinal cord injury but without neuropathic pain
Neurophysiology
Pain-related evoked potentials and nerve conduction studies
Cardiovascular test
Blood pressure control, orthostatic intolerance test, baro-reflex sensitivity, heart-rate variability
Experimental pain paradigms
Temporal summation of pain, conditioned pain modulation
Quantitative sensory testing
Thermal and mechanical sensory testing
Patients with peripheral neuropathy
Neurophysiology
Pain-related evoked potentials and nerve conduction studies
Cardiovascular test
Blood pressure control, orthostatic intolerance test, baro-reflex sensitivity, heart-rate variability
Experimental pain paradigms
Temporal summation of pain, conditioned pain modulation
Quantitative sensory testing
Thermal and mechanical sensory testing
Clinical pain phenotype
Pain drawings, plus and minus signs of pain
Healthy subjects
Neurophysiology
Pain-related evoked potentials and nerve conduction studies
Cardiovascular test
Blood pressure control, orthostatic intolerance test, baro-reflex sensitivity, heart-rate variability
Experimental pain paradigms
Temporal summation of pain, conditioned pain modulation
Quantitative sensory testing
Thermal and mechanical sensory testing
Interventions
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Neurophysiology
Pain-related evoked potentials and nerve conduction studies
Cardiovascular test
Blood pressure control, orthostatic intolerance test, baro-reflex sensitivity, heart-rate variability
Experimental pain paradigms
Temporal summation of pain, conditioned pain modulation
Quantitative sensory testing
Thermal and mechanical sensory testing
Clinical pain phenotype
Pain drawings, plus and minus signs of pain
Eligibility Criteria
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Inclusion Criteria
* Traumatic and non-traumatic etiology
* Para- and tetraplegic SCI
* Complete and incomplete SCI
* SCI with and without neuropathic pain
* SCI since less than one month
* SCI since more than one year
* Control cohorts with peripheral neuropathy:
* Aged between 18-80 years
* Neurological disorder affecting the peripheral nervous system (i.e., peripheral neuropathy)
* Peripheral neuropathy with or without neuropathic pain
* Peripheral neuropathy since less than one month
* Peripheral neuropathy since more than one year
* Control cohorts without neuropathy / healthy volunteers
* Aged between 18-80 years
* No medical condition affecting the peripheral and/or central nervous system (e.g., pain, systemic disease, psychological disorder)
Exclusion Criteria
* Pregnancy
* Medically manifested psychological disorder
* Medical condition affecting the peripheral and/or central nervous system other than the desired experimental condition (e.g., additional peripheral neuropathy in the SCI cohort)
18 Years
80 Years
ALL
Yes
Sponsors
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Swiss National Science Foundation
OTHER
University of Zurich
OTHER
Responsible Party
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Principal Investigators
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Patrick Freund, Prof. Dr. Dr.
Role: PRINCIPAL_INVESTIGATOR
University of Zurich
Locations
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Balgrist University Hospital
Zurich, Canton of Zurich, Switzerland
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2024-00134
Identifier Type: -
Identifier Source: org_study_id
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