Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome
NCT ID: NCT00968708
Last Updated: 2014-05-02
Study Results
Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.
View full resultsBasic Information
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COMPLETED
PHASE3
5380 participants
INTERVENTIONAL
2009-09-30
2013-06-30
Brief Summary
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Detailed Description
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Cardiovascular outcomes is of special interest in the type 2 diabetes mellitus population, particularly in type 2 diabetes mellitus patients who have cardiovascular disease and are at high risk for major adverse cardiac events, such as those patients who have had recent acute coronary syndrome.
This study has been designed to evaluate the cardiovascular safety of alogliptin versus placebo in addition to Standard of Care in adults with type 2 diabetes mellitus and acute coronary syndrome.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Placebo
Alogliptin placebo matching tablets, orally, once daily. Participants continued to receive standard of care for cardiovascular disease and diabetes according to regional guidelines.
Placebo
Alogliptin placebo matching tablets
Alogliptin
Alogliptin 25 mg, tablets, orally, once daily for participants with normal or mildly impaired renal function as defined by estimated glomerular filtration rate (eGFR) ≥ 60 mL/min). Alogliptin 12.5 mg, tablets, orally, once daily for participants with moderately impaired renal function (eGFR ≥30 and \<60 mL/min). Alogliptin 6.25 mg, tablets, orally, once daily for participants with severely impaired renal function or end stage renal disease (eGFR \<30 mL/min). Participants continued to receive standard of care for cardiovascular disease and diabetes according to regional guidelines.
Alogliptin
Alogliptin tablets
Interventions
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Alogliptin
Alogliptin tablets
Placebo
Alogliptin placebo matching tablets
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Is receiving monotherapy or combination antidiabetic therapy with a glycosylated hemoglobin level between 6.5% and 11.0%, inclusive, at Screening (between 7.0 and 11.0%, inclusive, if the participant's antidiabetic regimen includes insulin)
* Diagnosis of acute coronary syndrome within 15 to 90 days prior to randomization.
Exclusion Criteria
* Currently receiving a glucagon-like peptide-1 analogue for glycemic control of type 2 diabetes mellitus at Screening
* Received a dipeptidyl peptidase-4 inhibitor for either more than 14 days total or within the 3 months prior to Screening.
18 Years
ALL
No
Sponsors
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Takeda
INDUSTRY
Responsible Party
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Principal Investigators
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Medical Director Clinical Science
Role: STUDY_DIRECTOR
Takeda
Locations
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Birmingham, Alabama, United States
Dothan, Alabama, United States
Mobile, Alabama, United States
Muscle Shoals, Alabama, United States
Cottonwood, Arizona, United States
Goodyear, Arizona, United States
Mesa, Arizona, United States
Phoenix, Arizona, United States
Tucson, Arizona, United States
Little Rock, Arkansas, United States
Malvern, Arkansas, United States
Searcy, Arkansas, United States
White Hall, Arkansas, United States
Alameda, California, United States
Aliso Viejo, California, United States
Anaheim, California, United States
Bell Gardens, California, United States
Beverly Hills, California, United States
Chula Vista, California, United States
Corona, California, United States
Downey, California, United States
Escondido, California, United States
Fullerton, California, United States
Huntington Beach, California, United States
Huntington Park, California, United States
Inglewood, California, United States
La Mirada, California, United States
Lakewood, California, United States
Lancaster, California, United States
Lomita, California, United States
Long Beach, California, United States
Los Angeles, California, United States
Los Gatos, California, United States
Merced, California, United States
Newport Beach, California, United States
Northridge, California, United States
Oakland, California, United States
Palm Springs, California, United States
Pomona, California, United States
San Diego, California, United States
San Dimas, California, United States
Santa Ana, California, United States
Santa Clarita, California, United States
Stockton, California, United States
Tarzana, California, United States
Torrence, California, United States
Van Nuys, California, United States
Ventura, California, United States
Aurora, Colorado, United States
Colorado Springs, Colorado, United States
Bridgeport, Connecticut, United States
Washington D.C., District of Columbia, United States
Boca Raton, Florida, United States
Brandon, Florida, United States
Davie, Florida, United States
Daytona Beach, Florida, United States
Delray Beach, Florida, United States
Doral, Florida, United States
Fleming Island, Florida, United States
Fort Lauderdale, Florida, United States
Hollywood, Florida, United States
Jacksonville, Florida, United States
Kissimmee, Florida, United States
Lake Mary, Florida, United States
Largo, Florida, United States
Melbourne, Florida, United States
Miami, Florida, United States
Miami Lakes, Florida, United States
Naples, Florida, United States
New Smyrna Beach, Florida, United States
Ocala, Florida, United States
Orlando, Florida, United States
Palm Harbor, Florida, United States
Panama City, Florida, United States
Pembroke Pines, Florida, United States
Pensacola, Florida, United States
Saint Cloud, Florida, United States
Sarasota, Florida, United States
St. Petersburg, Florida, United States
Stuart, Florida, United States
Tampa, Florida, United States
Vero Beach, Florida, United States
Atlanta, Georgia, United States
Cartersville, Georgia, United States
Conyers, Georgia, United States
Dunwoody, Georgia, United States
Marietta, Georgia, United States
Savannah, Georgia, United States
Tucker, Georgia, United States
Waycross, Georgia, United States
Nampa, Idaho, United States
Aurora, Illinois, United States
Boilingbrook, Illinois, United States
Bolingbrook, Illinois, United States
Burr Ridge, Illinois, United States
Chicago, Illinois, United States
Jerseyville, Illinois, United States
Melrose Park, Illinois, United States
Moline, Illinois, United States
Peoria, Illinois, United States
Quincy, Illinois, United States
Springfield, Illinois, United States
Elkhart, Indiana, United States
Evansville, Indiana, United States
Indianapolis, Indiana, United States
Muncie, Indiana, United States
Munster, Indiana, United States
New Albany, Indiana, United States
Valparaiso, Indiana, United States
Council Bluffs, Iowa, United States
Shawnee Mission, Kansas, United States
Elizabethtown, Kentucky, United States
Lexington, Kentucky, United States
Madisonville, Kentucky, United States
Owensboro, Kentucky, United States
Alexandria, Louisiana, United States
Houma, Louisiana, United States
Lafayette, Louisiana, United States
Natchitoches, Louisiana, United States
New Orleans, Louisiana, United States
Slidell, Louisiana, United States
Biddeford, Maine, United States
Rockport, Maine, United States
Annapolis, Maryland, United States
Baltimore, Maryland, United States
Oxon Hill, Maryland, United States
Rockville, Maryland, United States
Boston, Massachusetts, United States
Brockton, Massachusetts, United States
Fall River, Massachusetts, United States
Alpena, Michigan, United States
Bridgman, Michigan, United States
Dearborn, Michigan, United States
Detroit, Michigan, United States
Kalamazoo, Michigan, United States
Lapeer, Michigan, United States
Livonia, Michigan, United States
Midland, Michigan, United States
Muskegon, Michigan, United States
Saginaw, Michigan, United States
Troy, Michigan, United States
Warren, Michigan, United States
Waterford, Michigan, United States
Ypsilanti, Michigan, United States
Duluth, Minnesota, United States
Minneapolis, Minnesota, United States
Rochester, Minnesota, United States
Chesterfield, Missouri, United States
Jefferson City, Missouri, United States
Kansas City, Missouri, United States
Saint Joseph, Missouri, United States
St Louis, Missouri, United States
Great Falls, Montana, United States
Omaha, Nebraska, United States
Las Vegas, Nevada, United States
Pahrump, Nevada, United States
Brick, New Jersey, United States
Bridgewater, New Jersey, United States
Camden, New Jersey, United States
Fort Lee, New Jersey, United States
Haddon Heights, New Jersey, United States
Linden, New Jersey, United States
New Brunswick, New Jersey, United States
Newark, New Jersey, United States
Ridgewood, New Jersey, United States
Sewell, New Jersey, United States
Sicklerville, New Jersey, United States
South Plainfield, New Jersey, United States
Albuquerque, New Mexico, United States
Cortlandt Manor, New York, United States
Freeport, New York, United States
Huntington, New York, United States
Johnson City, New York, United States
Kingston, New York, United States
New Hartford, New York, United States
New York, New York, United States
Rochester, New York, United States
Saratoga Springs, New York, United States
Springfield Gardens, New York, United States
The Bronx, New York, United States
Valhalla, New York, United States
Williamsville, New York, United States
Asheville, North Carolina, United States
Burlington, North Carolina, United States
Charlotte, North Carolina, United States
Elizabeth City, North Carolina, United States
Forsyth, North Carolina, United States
Greensboro, North Carolina, United States
Hickory, North Carolina, United States
Lenoir, North Carolina, United States
Smithfield, North Carolina, United States
Wilmington, North Carolina, United States
Winston-Salem, North Carolina, United States
Bismarck, North Dakota, United States
Fargo, North Dakota, United States
Minot, North Dakota, United States
Akron, Ohio, United States
Athens, Ohio, United States
Berea, Ohio, United States
Boardman, Ohio, United States
Carlisle, Ohio, United States
Centerville, Ohio, United States
Cincinnati, Ohio, United States
Cleveland, Ohio, United States
Columbus, Ohio, United States
Franklin, Ohio, United States
Lorain, Ohio, United States
Marion, Ohio, United States
Maumee, Ohio, United States
Middleburg Heights, Ohio, United States
Springfield, Ohio, United States
Toledo, Ohio, United States
Westlake, Ohio, United States
Zanesville, Ohio, United States
Bartlesville, Oklahoma, United States
Oklahoma City, Oklahoma, United States
Yukon, Oklahoma, United States
Bend, Oregon, United States
Corvallis, Oregon, United States
Hillsboro, Oregon, United States
Portland, Oregon, United States
Altoona, Pennsylvania, United States
Bethlehem, Pennsylvania, United States
Clymer, Pennsylvania, United States
Fleetwood, Pennsylvania, United States
Langhorne, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Schwenksville, Pennsylvania, United States
Scotland, Pennsylvania, United States
Sellersville, Pennsylvania, United States
Yardley, Pennsylvania, United States
East Providence, Rhode Island, United States
Beaufort, South Carolina, United States
Easley, South Carolina, United States
Florence, South Carolina, United States
Spartanburg, South Carolina, United States
Taylors, South Carolina, United States
Sioux Falls, South Dakota, United States
Bartlett, Tennessee, United States
Bristol, Tennessee, United States
Cleveland, Tennessee, United States
Franklin, Tennessee, United States
Germantown, Tennessee, United States
Jackson, Tennessee, United States
Johnson City, Tennessee, United States
Kingsport, Tennessee, United States
Knoxville, Tennessee, United States
Memphis, Tennessee, United States
Murfreesboro, Tennessee, United States
Nashville, Tennessee, United States
Oak Ridge, Tennessee, United States
Austin, Texas, United States
Beaumont, Texas, United States
Carrollton, Texas, United States
Dallas, Texas, United States
Denton, Texas, United States
Edinburg, Texas, United States
Fort Worth, Texas, United States
Grapevine, Texas, United States
Houston, Texas, United States
McKinney, Texas, United States
North Richland Hills, Texas, United States
Plano, Texas, United States
Saginaw, Texas, United States
San Antonio, Texas, United States
Southlake, Texas, United States
Temple, Texas, United States
Tomball, Texas, United States
Bountiful, Utah, United States
Ogden, Utah, United States
Salt Lake City, Utah, United States
Bennington, Vermont, United States
South Burlington, Vermont, United States
Burke, Virginia, United States
Charlottesville, Virginia, United States
Galax, Virginia, United States
Lakeridge, Virginia, United States
Manassas, Virginia, United States
Norfolk, Virginia, United States
Richmond, Virginia, United States
Roanoke, Virginia, United States
Suffolk, Virginia, United States
Virginia Beach, Virginia, United States
Everett, Washington, United States
Tacoma, Washington, United States
Beloit, Wisconsin, United States
Green Bay, Wisconsin, United States
Madison, Wisconsin, United States
Manitowoc, Wisconsin, United States
Milwaukee, Wisconsin, United States
Waukesha, Wisconsin, United States
Bahía Blanca, , Argentina
Buenos Aires, , Argentina
C0rdoba, , Argentina
Capital Federal, Buenos Aires, , Argentina
Capital Federal, , Argentina
Carlos Paz, C0rdoba, , Argentina
Ciudad Aut0noma de Buenos Aires, , Argentina
Ciudad de C0rdoba, , Argentina
Cordoba - Cordoba, , Argentina
Corrientes, , Argentina
Córdoba, , Argentina
Derqui Pilar, Buenos Aires, , Argentina
Formosa, , Argentina
Haedo, Buenos Aires, , Argentina
La Plata, , Argentina
La Plata, Buenos Aires, , Argentina
Mar del Plata, , Argentina
Mar Del Plata, Provincia de Buenos Aires, , Argentina
Mendoza, , Argentina
Moron, Buenos Aires, , Argentina
Olivos, , Argentina
Quilmes, , Argentina
Ramos Mejia, Buenos Aries, , Argentina
Ramos Mejía, , Argentina
Rosario, , Argentina
Rosario - Santa Fe, , Argentina
Rosario, Provincia de Santa Fe, , Argentina
Salta, , Argentina
San Isidro, , Argentina
San Juan, San Juan, , Argentina
San Justo, , Argentina
San Luis, , Argentina
San Miguel de Tucumán, , Argentina
San Salvador de Jujuy, , Argentina
Santa Fe, , Argentina
Trelew, Chubut, , Argentina
Villa María, , Argentina
Broken Hill, New South Wales, Australia
Kogarah, New South Wales, Australia
Milton, Queensland, Australia
Nambour, Queensland, Australia
Hobart, Tasmania, Australia
Fitzroy, Victoria, Australia
Frankston, Victoria, Australia
Heidelberg, Victoria, Australia
Prahran, Victoria, Australia
Adelaide, SA, , Australia
Bruce, , Australia
Feldkirch, , Austria
Graz, , Austria
Salzburg, , Austria
Vienna, , Austria
Antwerp, , Belgium
Bonheiden, , Belgium
Brasschaat, , Belgium
Brussels, , Belgium
Ghent, , Belgium
La Louvière, , Belgium
Curitiba, Paraná, Brazil
Rio de Janeiro, Rio de Janeiro, Brazil
São Paulo, São Paulo, Brazil
Tatuí, São Paulo, Brazil
Aracaju, Sergipe, , Brazil
Belem - PA, , Brazil
Belo Horizonte - MG, , Brazil
Belo Horizonte, Minas Gerais, , Brazil
Blumenau, , Brazil
Brasilia - DF, , Brazil
Brasilia, Distrito Federal, , Brazil
Campina Grande do Sul, , Brazil
Campinas, Sao Paulo, , Brazil
Campo Grande, Mato Grosso Do Sul, , Brazil
Curitiba, Parana, , Brazil
Fortaleza - CE, , Brazil
Fortaleza, Ceara, , Brazil
Goiania, Goias, , Brazil
Goiânia, , Brazil
Joinville, , Brazil
Londrina/PR, , Brazil
Macei0, , Brazil
Marilia, Sao Paulo, , Brazil
Marília, , Brazil
Mogi das Cruzes, , Brazil
Natal, , Brazil
Natal, RN, , Brazil
Passo Fundo, Rio Grande Do Sul, , Brazil
Porto Alegre, , Brazil
Porto Alegre - RS, , Brazil
Porto Alegre, Rio Grande Do Sul, , Brazil
Recife, , Brazil
Recife, PE, , Brazil
Recife, Pernambuco, , Brazil
Rio de Janeiro, , Brazil
Rio de Janeiro - RJ, , Brazil
Salvador - BA, , Brazil
Salvador, Bahia, , Brazil
Santo André, , Brazil
Sao Jose Do Rio Preto, Sao Paulo, , Brazil
Sao Jose Do Rio Preto- SP, , Brazil
Sao Jose, Santa Catarina, , Brazil
Sao Paulo, Sao Paulo, , Brazil
Sao Paulo, SP, , Brazil
São José do Rio Preto, , Brazil
São Paulo, , Brazil
Sobral, CE, , Brazil
Taguatinga, , Brazil
Uberlandia, Minas Gerais, , Brazil
Votuporanga, , Brazil
Blagoevgrad, , Bulgaria
Dimitrovgrad, , Bulgaria
Kazanlak, , Bulgaria
Lovech, , Bulgaria
Pleven, , Bulgaria
Plovdiv, , Bulgaria
Sevlievo, , Bulgaria
Smolyan, , Bulgaria
Sofia, , Bulgaria
Stara Zagora, , Bulgaria
Varna, , Bulgaria
Calgary, Alberta, Canada
Edmonton, Alberta, Canada
Abbotsford, British Columbia, Canada
Kelowna, British Columbia, Canada
Vancouver, British Columbia, Canada
Victoria, British Columbia, Canada
Grand Falls-Windsor, Newfoundland and Labrador, Canada
St. John's, Newfoundland and Labrador, Canada
Halifax, Nova Scotia, Canada
Ajax, Ontario, Canada
Cambridge, Ontario, Canada
Greater Sudbury, Ontario, Canada
Hamilton, Ontario, Canada
Newmarket, Ontario, Canada
Niagara Falls, Ontario, Canada
Ontario, Ontario, Canada
Oshawa, Ontario, Canada
Pickering, Ontario, Canada
Smiths Falls, Ontario, Canada
Toronto, Ontario, Canada
Greenfield Park, Quebec, Canada
Greenfield, Quebec, Canada
Lachine, Quebec, Canada
Mount Royal, Quebec, Canada
Pointe-Claire, Quebec, Canada
Québec, Quebec, Canada
Saint-Jérôme, Quebec, Canada
Sainte-Foy, Quebec, Canada
Sherbrooke, Quebec, Canada
Terrebonne, Quebec, Canada
Antofagasta, , Chile
Antofagasta, Region II, , Chile
Iquique, Region I, , Chile
Osorno, , Chile
Rancagua, , Chile
Santiago, , Chile
Talcahuano, , Chile
Temuco, , Chile
Temuco, Region de La Araucania, , Chile
Viña del Mar, , Chile
Barranquilla, , Colombia
Bogotá, , Colombia
Bucaramanga, , Colombia
Medellín, , Colombia
Čakovec, , Croatia
Krapinske Toplice, , Croatia
Osijek, , Croatia
Rijeka, , Croatia
Sisak, , Croatia
Split, , Croatia
Virovitica, , Croatia
Zadar, , Croatia
Zagreb, , Croatia
Čáslav, , Czechia
Hradec Králové, , Czechia
Olomouc, , Czechia
Ostrava - Vitkovice, , Czechia
Zlín, , Czechia
Znojmo, , Czechia
Herlev, , Denmark
Herning, , Denmark
København NV, , Denmark
Alexandria, , Egypt
Giza, , Egypt
Monofia, , Egypt
Helsinki, , Finland
Jyväskylä, , Finland
Kokkola, , Finland
Kuopio, , Finland
Tampere, , Finland
Turku, , Finland
Bordeaux, , France
Corbeil-Essonnes, , France
Créteil, , France
Dijon, , France
La Rochelle, , France
Lille, , France
Montpellier, , France
Narbonne, , France
Paris, , France
Pau, , France
Pessac, , France
Rennes, , France
Toulouse, , France
Bad Nauheim, , Germany
Bensheim, , Germany
Berlin, , Germany
Cologne, , Germany
Dortmund, , Germany
Dresden, , Germany
Essen, , Germany
Halle, , Germany
Jena, , Germany
Kassel, , Germany
Leipzig, , Germany
Mainz, , Germany
Mannheim, , Germany
München, , Germany
Münster, , Germany
Neumünster, , Germany
Neuwied, , Germany
Sankt Ingbert, , Germany
Siegen, , Germany
Wangen, , Germany
Marousi, , Greece
Guatemala City, , Guatemala
Quetzaltenango, , Guatemala
Hong Kong, , Hong Kong
Kowloon, , Hong Kong
Shatin, , Hong Kong
Tsuen Wan, , Hong Kong
Budaörs, , Hungary
Budapest, , Hungary
Debrecen, , Hungary
Dunaújváros, , Hungary
Gyula, , Hungary
H0dmezovasarhely, , Hungary
Kaposvár, , Hungary
Kecskemét, , Hungary
Nagykanizsa, , Hungary
Pécs, , Hungary
Sopron, , Hungary
Szentes, , Hungary
Székesfehérvár, , Hungary
Szombathely, , Hungary
Zalaegerszeg, , Hungary
Hyderabad, Andhra Pradesh, India
Nellore, Andhra Pradesh, India
Vijayawada, Andhra Pradesh, India
Visakhapatnam, Andhra Pradesh, India
Perumbākkam, Chennai, India
Ahmedabad, Gujarat, India
Anand, Gujarat, India
Surat, Gujarat, India
Vadodara, Gujarat, India
Bangalore, Karnataka, India
Belagavi, Karnataka, India
Mangalore, Karnataka, India
Manipal, Karnataka, India
Mysore, Karnataka, India
Kochi, Kerala, India
Thiruvananthapuram, Kerala, India
Thrissur, Kerala, India
Trivandrum, Kerala, India
Aurangabad, Maharashtra, India
Mumbai, Maharashtra, India
Nagpur, Maharashtra, India
Nashik, Maharashtra, India
Pune, Maharashtra, India
Delhi, National Capital Territory of Delhi, India
New Delhi, National Capital Territory of Delhi, India
Jalandhar, Punjab, India
Ludhiana, Punjab, India
Jaipur, Rajasthan, India
Chennai, Tamil Nadu, India
Coimbatore, Tamil Nadu, India
Madurai, Tamil Nadu, India
Kolkata, West Bengal, India
Ashkelon, , Israel
Beersheba, , Israel
Haifa, , Israel
Holon, , Israel
Jerusalem, , Israel
Kfar Saba, , Israel
Nahariya, , Israel
Nazareth, , Israel
Petah Tikva, , Israel
Rehovot, , Israel
Rishon LeZiyyon, , Israel
Safed, , Israel
Tel Aviv, , Israel
Tiberias, , Israel
Cosenza, , Italy
Isernia, , Italy
Milan, , Italy
Napoli, , Italy
Palermo, , Italy
Pavia, , Italy
Ravenna, , Italy
Roma, , Italy
Sesto San Giovanni, , Italy
Aichi-gun, Aichi-ken, Japan
Nagoya, Aichi-ken, Japan
Seto, Aichi-ken, Japan
Funabashi, Chiba, Japan
Kashiwa, Chiba, Japan
Imabari, Ehime, Japan
Fukuoka, Fukuoka, Japan
Kasuga, Fukuoka, Japan
Kitakyushu, Fukuoka, Japan
Ohkawa-city, Fukuoka, Japan
Fukushima, Fukushima, Japan
Gifu, Gifu, Japan
Shibukawa, Gunma, Japan
Takasaki, Gunma, Japan
Higashihiroshima, Hiroshima, Japan
Tomakomai, Hokkaido, Japan
Amagasaki, Hyōgo, Japan
Kanazawa, Ishikawa-ken, Japan
Sakaidechō, Kagawa-ken, Japan
Kawasaki, Kanagawa, Japan
Sagamihara-shi, Kanagawa, Japan
Nankoku, Kochi, Japan
Kumamoto, Kumamoto, Japan
Uji-shi, Kyoto, Japan
Matsusaka, Mie-ken, Japan
Nagasaki, Nagasaki, Japan
Niigata, Niigata, Japan
Ōita, Oita Prefecture, Japan
Okayama, Okayama-ken, Japan
Shimajiri-gun, Okinawa, Japan
Tomigusuku, Okinawa, Japan
Kishiwada, Osaka, Japan
Matsubara, Osaka, Japan
Yao-shi, Osaka, Japan
Saga, Saga-ken, Japan
Ageo, Saitama, Japan
Wako, Saitama, Japan
Hamada, Shimane, Japan
Suntou-gun, Shizuoka, Japan
Komatsushimachō, Tokushima, Japan
Tokushima, Tokushima, Japan
Hino, Tokyo, Japan
Tachikawa, Tokyo, Japan
Tokyo, Tokyo, Japan
Iwakuni-shi, Yamaguchi, Japan
Dasman, , Kuwait
Daugavpils, , Latvia
Ogre, , Latvia
Riga, , Latvia
Tukums, , Latvia
Valmiera, , Latvia
Kaunas, , Lithuania
Kėdainiai, , Lithuania
Klaipėda, , Lithuania
Palanga, , Lithuania
Panevezys, , Lithuania
Vilnius, , Lithuania
Alor Star, , Malaysia
Batu Caves, , Malaysia
George Town, , Malaysia
Kuala Lumpur, , Malaysia
Kuala Selangor, , Malaysia
Kuantan, , Malaysia
Kubang Kerian, , Malaysia
Pulau Pinang, , Malaysia
Acapulco, Guerrero, , Mexico
Aguascalientes, , Mexico
Chihuahua City, , Mexico
Chihuhua, Chihuhua, , Mexico
Ciudad Obregon, Sonora, , Mexico
Cuernavaca, , Mexico
Cuernavaca, Morelos, , Mexico
Culiacán, , Mexico
Durango, , Mexico
Guadalajara, , Mexico
Guadalajara, Jalisco, , Mexico
Merida, Yucatan, , Mexico
Metepec, , Mexico
Mexicali, Baja California, , Mexico
Mexico City, , Mexico
Mexico City, Mexico, , Mexico
México, , Mexico
Monclova, Coahuila, , Mexico
Monterrey, , Mexico
Monterrey, NL, , Mexico
Monterrey, Nuevo Le0n, , Mexico
Monterrey, Nuevo Leon, , Mexico
Morelia, Michoacan, , Mexico
Pachuca, , Mexico
Saltillo, , Mexico
Saltillo, Coahuila, , Mexico
San Luis Potosi.SLP, , Mexico
San Luis Potosí City, , Mexico
Tijuana, Baja California Norte, , Mexico
Tlalnepantla, , Mexico
Tlalnepantla, Edo de Mexico, , Mexico
Xalapa, Veracruz, , Mexico
Zapopan, , Mexico
Auckland, , New Zealand
Christchurch, , New Zealand
Otahuhu, , New Zealand
Palmerston North, , New Zealand
Takapuna, , New Zealand
Tauranga, , New Zealand
Arequipa, , Peru
Bellavista, , Peru
Callao, , Peru
Cusco, , Peru
Huacho, , Peru
Ica, , Peru
La Victoria, Lima, , Peru
Lima, , Peru
Lima San Isidro, , Peru
Los Olivos, , Peru
Miraflores, Lima, , Peru
Piura, , Peru
San Isidro, Lima, , Peru
San Miguel, Lima, , Peru
Trujillo, , Peru
Trujillo, La Libertad, , Peru
Baguio City, , Philippines
Dasmariñas, , Philippines
Davao City, , Philippines
Iloilo City, , Philippines
Laoag, , Philippines
Makati City, , Philippines
Manila, , Philippines
Marikina City, , Philippines
Pasig, , Philippines
Quezon City, , Philippines
Bialystok, , Poland
Bydgoszcz, , Poland
Częstochowa, , Poland
Dąbrowa Górnicza, , Poland
Elblag, , Poland
Gdansk, , Poland
Gdynia, , Poland
Grodzisk Mazowiecki, , Poland
Inowrocław, , Poland
Katowice, , Poland
Kielce, , Poland
Krakow, , Poland
Legnica, , Poland
Lodz, , Poland
Lubartów, , Poland
Lublin, , Poland
Puławy, , Poland
Płock, , Poland
Radom, , Poland
Ruda Śląska, , Poland
Skierniewice, , Poland
Szczecin, , Poland
Słupsk, , Poland
Torun, , Poland
Warsaw, , Poland
Wroclaw, , Poland
Zabrze, , Poland
Zgierz, , Poland
Coimbra, , Portugal
Faro, , Portugal
Lisbon, , Portugal
Vila Real, , Portugal
Aibonito, PR, Puerto Rico
Halo Rey, PR, Puerto Rico
Ponce, PR, Puerto Rico
Salinas, PR, Puerto Rico
Santurce, PR, Puerto Rico
Carolina, , Puerto Rico
Cidra, , Puerto Rico
Levittown, , Puerto Rico
Manatí, , Puerto Rico
Mayagüez, , Puerto Rico
San Juan, , Puerto Rico
Bacau, , Romania
Baia Mare, , Romania
Brasov, , Romania
Brăila, , Romania
Bucharest, , Romania
Buzău, , Romania
Galati, , Romania
Iași, , Romania
Oradea, , Romania
Ploieşti, , Romania
Satu Mare, , Romania
Târgu Mureş, , Romania
Timișoara, , Romania
Arkhangelsk, , Russia
Barnaul, , Russia
Ivanovo, , Russia
Kazan', , Russia
Kemerovo, , Russia
Krasnodar, , Russia
Krasnoyarsk, , Russia
Kursk, , Russia
Moscow, , Russia
Nizhny Novgorod, , Russia
Novosibirsk, , Russia
Rostov-on-Don, , Russia
Saint Petersburg, , Russia
Saratov, , Russia
Ufa, , Russia
Volgograd, , Russia
Vsevolozhsk, , Russia
Belgrade, , Serbia
Niš, , Serbia
Bardejov, , Slovakia
Bratislava, , Slovakia
Dolný Kubín, , Slovakia
Komárno, , Slovakia
Kosice - Saca, , Slovakia
Košice, , Slovakia
Levice, , Slovakia
Liptovský Hrádok, , Slovakia
Nové Mesto nad Váhom, , Slovakia
Nové Zámky, , Slovakia
Považská Bystrica, , Slovakia
Rimavská Sobota, , Slovakia
Ružomberok, , Slovakia
Svidník, , Slovakia
Žilina, , Slovakia
Port Elizabeth, Eastern Cape, South Africa
Johannesburg, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Durban, KwaZulu-Natal, South Africa
Cape Town, Western Cape, South Africa
Paarl, Western Cape, South Africa
Somerset West, Western Cape, South Africa
Tygerberg, Western Cape, South Africa
Worcester, Western Cape, South Africa
Durban, , South Africa
Pretoria, , South Africa
Anyang, , South Korea
Busan, , South Korea
Daegu, , South Korea
Goyang-si, , South Korea
Guri-si, , South Korea
Gyeonggi-do, , South Korea
Jeonju, , South Korea
Kangwon-do, , South Korea
Pusan, , South Korea
Seoul, , South Korea
Suwon, , South Korea
Yangsan, , South Korea
Zaragoza, Arag0n, Spain
Cuenca, Castille-La Mancha, Spain
Barcelona, Catalonia, Spain
Figueres, Catalonia, Spain
A Coruña, Galicia, Spain
Santiago de Compostela, Galicia, Spain
Oviedo, Principality of Asturias, Spain
Torrevieja, Valencia, Spain
Bacarot, , Spain
Mérida, , Spain
Palma de Mallorca, , Spain
Dalby, , Sweden
Falköping, , Sweden
Gothenburg, , Sweden
Härnösand, , Sweden
Kristianstad, , Sweden
Malmo, , Sweden
Motala, , Sweden
Stockholm, , Sweden
Kaohsiung City, , Taiwan
Taipei County, , Taiwan
Taoyuan District, , Taiwan
Amphure Muang, , Thailand
Bangkojk, , Thailand
Bangkok, , Thailand
Chiang Mai, , Thailand
Chiang Rai, , Thailand
Muang, , Thailand
Nakhon Ratchasima, , Thailand
Pathumwan, , Thailand
Patumthani, , Thailand
Phitsanulok, , Thailand
Phrae, , Thailand
Ankara, Balgat, , Turkey (Türkiye)
Antalya, , Turkey (Türkiye)
Istanbul, , Turkey (Türkiye)
Kayseri, , Turkey (Türkiye)
Konya, , Turkey (Türkiye)
Donetsk, , Ukraine
Ivano-Frankivsk, , Ukraine
Kharkiv, , Ukraine
Kyiv, , Ukraine
Lviv, , Ukraine
Odesa, , Ukraine
Poltava, , Ukraine
Simferopol, , Ukraine
Vinnytsia, , Ukraine
Zaporizhzhya, , Ukraine
Abu Dhabi, , United Arab Emirates
Barnsley, , United Kingdom
Bath, , United Kingdom
Birmingham, , United Kingdom
Bournemouth, , United Kingdom
Carshalton, , United Kingdom
Chertsey, , United Kingdom
Chichester, , United Kingdom
Colchester, , United Kingdom
Coventry, , United Kingdom
Croydon, , United Kingdom
Doncaster, , United Kingdom
Glasgow, , United Kingdom
Hull, , United Kingdom
Inverness, , United Kingdom
Kirkcaldy, , United Kingdom
Liverpool, , United Kingdom
Livingston, , United Kingdom
London, , United Kingdom
Nuneaton, , United Kingdom
Stevenage, , United Kingdom
Sunderland, , United Kingdom
Torquay, , United Kingdom
Wakefield, , United Kingdom
West Midlands, , United Kingdom
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Ferreira JP, Rossignol P, Bakris G, Mehta C, White WB, Zannad F. Blood and Urine Biomarkers Predicting Worsening Kidney Function in Patients with Type 2 Diabetes Post-Acute Coronary Syndrome: An Analysis from the EXAMINE Trial. Am J Nephrol. 2021;52(12):969-976. doi: 10.1159/000519436. Epub 2021 Dec 6.
Ferreira JP, Mehta C, Sharma A, Nissen SE, Rossignol P, Zannad F. Alogliptin after acute coronary syndrome in patients with type 2 diabetes: a renal function stratified analysis of the EXAMINE trial. BMC Med. 2020 Jun 4;18(1):165. doi: 10.1186/s12916-020-01616-8.
Sharma A, Vaduganathan M, Ferreira JP, Liu Y, Bakris GL, Cannon CP, White WB, Zannad F. Clinical and Biomarker Predictors of Expanded Heart Failure Outcomes in Patients With Type 2 Diabetes Mellitus After a Recent Acute Coronary Syndrome: Insights From the EXAMINE Trial. J Am Heart Assoc. 2020 Jan 7;9(1):e012797. doi: 10.1161/JAHA.119.012797. Epub 2020 Jan 4.
White WB, Jalil F, Cushman WC, Bakris GL, Bergenstal R, Heller SR, Liu Y, Mehta C, Zannad F, Cannon CP. Average Clinician-Measured Blood Pressures and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Ischemic Heart Disease in the EXAMINE Trial. J Am Heart Assoc. 2018 Oct 16;7(20):e009114. doi: 10.1161/JAHA.118.009114.
Jarolim P, White WB, Cannon CP, Gao Q, Morrow DA. Serial Measurement of Natriuretic Peptides and Cardiovascular Outcomes in Patients With Type 2 Diabetes in the EXAMINE Trial. Diabetes Care. 2018 Jul;41(7):1510-1515. doi: 10.2337/dc18-0109. Epub 2018 May 30.
Sharma A, Cannon CP, White WB, Liu Y, Bakris GL, Cushman WC, Zannad F. Early and Chronic Dipeptidyl-Peptidase-IV Inhibition and Cardiovascular Events in Patients With Type 2 Diabetes Mellitus After an Acute Coronary Syndrome: A Landmark Analysis of the EXAMINE Trial. J Am Heart Assoc. 2018 May 16;7(11):e007649. doi: 10.1161/JAHA.117.007649.
White WB, Heller SR, Cannon CP, Howitt H, Khunti K, Bergenstal RM; EXAMINE Investigators. Alogliptin in Patients with Type 2 Diabetes Receiving Metformin and Sulfonylurea Therapies in the EXAMINE Trial. Am J Med. 2018 Jul;131(7):813-819.e5. doi: 10.1016/j.amjmed.2018.02.023. Epub 2018 Mar 23.
Hwang YC, Morrow DA, Cannon CP, Liu Y, Bergenstal R, Heller S, Mehta C, Cushman W, Bakris GL, Zannad F, White WB. High-sensitivity C-reactive protein, low-density lipoprotein cholesterol and cardiovascular outcomes in patients with type 2 diabetes in the EXAMINE (Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care) trial. Diabetes Obes Metab. 2018 Mar;20(3):654-659. doi: 10.1111/dom.13136. Epub 2017 Nov 21.
Kay S, Strickson A, Puelles J, Selby R, Benson E, Tolley K. Comparative Effectiveness of Adding Alogliptin to Metformin Plus Sulfonylurea with Other DPP-4 Inhibitors in Type 2 Diabetes: A Systematic Review and Network Meta-Analysis. Diabetes Ther. 2017 Apr;8(2):251-273. doi: 10.1007/s13300-017-0245-8. Epub 2017 Mar 8.
Cavender MA, White WB, Jarolim P, Bakris GL, Cushman WC, Kupfer S, Gao Q, Mehta CR, Zannad F, Cannon CP, Morrow DA. Serial Measurement of High-Sensitivity Troponin I and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus in the EXAMINE Trial (Examination of Cardiovascular Outcomes With Alogliptin Versus Standard of Care). Circulation. 2017 May 16;135(20):1911-1921. doi: 10.1161/CIRCULATIONAHA.116.024632. Epub 2017 Feb 28.
White WB, Kupfer S, Zannad F, Mehta CR, Wilson CA, Lei L, Bakris GL, Nissen SE, Cushman WC, Heller SR, Bergenstal RM, Fleck PR, Cannon CP; EXAMINE Investigators. Cardiovascular Mortality in Patients With Type 2 Diabetes and Recent Acute Coronary Syndromes From the EXAMINE Trial. Diabetes Care. 2016 Jul;39(7):1267-73. doi: 10.2337/dc16-0303. Epub 2016 Jun 11.
Zannad F, Cannon CP, Cushman WC, Bakris GL, Menon V, Perez AT, Fleck PR, Mehta CR, Kupfer S, Wilson C, Lam H, White WB; EXAMINE Investigators. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial. Lancet. 2015 May 23;385(9982):2067-76. doi: 10.1016/S0140-6736(14)62225-X. Epub 2015 Mar 10.
White WB, Cannon CP, Heller SR, Nissen SE, Bergenstal RM, Bakris GL, Perez AT, Fleck PR, Mehta CR, Kupfer S, Wilson C, Cushman WC, Zannad F; EXAMINE Investigators. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med. 2013 Oct 3;369(14):1327-35. doi: 10.1056/NEJMoa1305889. Epub 2013 Sep 2.
White WB, Bakris GL, Bergenstal RM, Cannon CP, Cushman WC, Fleck P, Heller S, Mehta C, Nissen SE, Perez A, Wilson C, Zannad F. EXamination of cArdiovascular outcoMes with alogliptIN versus standard of carE in patients with type 2 diabetes mellitus and acute coronary syndrome (EXAMINE): a cardiovascular safety study of the dipeptidyl peptidase 4 inhibitor alogliptin in patients with type 2 diabetes with acute coronary syndrome. Am Heart J. 2011 Oct;162(4):620-626.e1. doi: 10.1016/j.ahj.2011.08.004. Epub 2011 Sep 14.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
U1111-1111-6825
Identifier Type: REGISTRY
Identifier Source: secondary_id
2009-011222-34
Identifier Type: REGISTRY
Identifier Source: secondary_id
JapicCTI-101246
Identifier Type: REGISTRY
Identifier Source: secondary_id
DOH-27-0310-3047
Identifier Type: REGISTRY
Identifier Source: secondary_id
09/H0709/63
Identifier Type: REGISTRY
Identifier Source: secondary_id
CTRI/2010/091/000046
Identifier Type: REGISTRY
Identifier Source: secondary_id
2009-011222-34
Identifier Type: REGISTRY
Identifier Source: secondary_id
2009-011222-34
Identifier Type: REGISTRY
Identifier Source: secondary_id
NMRR-09-872-4471
Identifier Type: REGISTRY
Identifier Source: secondary_id
SYR-322_402
Identifier Type: -
Identifier Source: org_study_id
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