Effect of Passive Smoking on Platelet Function and Endothelial Function

NCT ID: NCT00923988

Last Updated: 2009-08-11

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-06-30
• Study Completion Date: 2009-08-31

Brief Summary

Passive smoking is associated with an increased risk for cardiovascular events. However, the exact mechanisms by which passive smoking affects cardiovascular health are not entirely understood. In the present study, the researchers investigate the effects of short-term exposure to secondhand smoke on platelet function and peripheral microvascular endothelial function in healthy individuals. For this purpose, platelet function and endothelial function are measured before and after a 1-hour exposure to secondhand smoke in a concentration that is encountered in bars and restaurants without smoke-free policies. The researchers' hypothesis is that short-term exposure leads to platelet activation and impairment of endothelial function.

Conditions

Endothelial Function; Platelet Aggregation

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Interventions

secondhand smoke exposure

Participants will be exposed to secondhand smoke for one hour. As a measure of secondhand smoke exposition, room carbon monoxide concentration will be continuously measured using an Ambient Carbon Monoxide Monitor APMA-360 and kept constant between 4.5-6.0 ppm. Levels in this magnitude are typically seen in smoking areas of restaurants and bars.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• healthy individuals
• nonsmokers
• no regular medication (in particular no drugs affecting platelet function or vascular function)

Exclusion Criteria

• exposition to secondhand smoke within 1 week before inclusion
• use of drugs affecting platelet function or vascular function within 1 week before study inclusion

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Kantonsspital Graubünden

OTHER

Sponsor Role: lead

Responsible Party

Kantonsspital Graubuenden, Chur, Switzerland

Principal Investigators

Piero O. Bonetti, MD

Role: PRINCIPAL_INVESTIGATOR

Division of Cardiology, Department of Internal Medicine, Kantonsspital Graubuenden, Loestrasse 170, CH-7000 Chur, Switzerland

Locations

Kantonsspital Graubuenden

Chur, , Switzerland

Countries

Switzerland

Other Identifiers

SHS-EF

Identifier Type: -

Identifier Source: org_study_id