Acute Effects of Smoking on Airway Dendritic Cells

NCT ID: NCT00740896

Last Updated: 2009-04-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-06-30

Study Completion Date

2008-12-31

Brief Summary

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Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.

Detailed Description

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Conditions

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Tobacco Use Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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1

Participants smoke 8 cigarettes in 4 hours.

Group Type ACTIVE_COMPARATOR

Smoking

Intervention Type BEHAVIORAL

Active Comparator: Participants smoke 8 cigarettes in 4 hours.

2

Participants are not allowed to smoke for 4 hours.

Group Type SHAM_COMPARATOR

Smoking

Intervention Type BEHAVIORAL

Sham Comparator: Participants are not allowed to smoke for 4 hours.

Interventions

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Smoking

Active Comparator: Participants smoke 8 cigarettes in 4 hours.

Intervention Type BEHAVIORAL

Smoking

Sham Comparator: Participants are not allowed to smoke for 4 hours.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Active smoking (at least 10 cigarettes per day)
* Age \> 18 years

Exclusion Criteria

* Any chronic diseases
* Any regular medication
* Any signs or symptoms of an acute infection
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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German Research Foundation

OTHER

Sponsor Role collaborator

University of Rostock

OTHER

Sponsor Role lead

Responsible Party

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University of Rostock

Principal Investigators

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Johann C. Virchow, Professor, MD, FRCP, FCCP

Role: STUDY_CHAIR

University of Rostock

Locations

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University of Rostock

Rostock, , Germany

Site Status

Countries

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Germany

References

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Bratke K, Klug M, Bier A, Julius P, Kuepper M, Virchow JC, Lommatzsch M. Function-associated surface molecules on airway dendritic cells in cigarette smokers. Am J Respir Cell Mol Biol. 2008 Jun;38(6):655-60. doi: 10.1165/rcmb.2007-0400OC. Epub 2008 Jan 18.

Reference Type BACKGROUND
PMID: 18203971 (View on PubMed)

Other Identifiers

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LO-2222

Identifier Type: -

Identifier Source: org_study_id

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