Computed Tomography Coronary Angiography (CTCA) and Coronary Flow in Stenosis Analysis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-08-31

Study Completion Date

2008-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The investigators' rationale was to evaluate whether a 64-slice CT scanner allows accurate measurement of computed tomographic changes in coronary artery flow profiles and whether CT flow measurements are suitable for classifying the significance and hemodynamic relevance of a stenosis and thereby supplement as a functional parameter for morphological stenosis analysis.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

320-slice Coronary Computed Tomography (CT) Angiography

NCT00721851

Coronary Artery Stenosis

COMPLETED

Plaque Registration and Event Detection In Computed Tomography

NCT00991835

Atherosclerosis Cardiovascular Diseases Coronary Artery Disease

UNKNOWN

Evaluation of CTCA in Assessing Plaque Pathology and Physiology

NCT03556644

Coronary Artery Disease

COMPLETED NA

Clinical Values of Dose Reduction Techniques in Computed Tomography (CT) Coronary Artery Imaging With 64-row Multi-Slice Helical CT

NCT01060657

Coronary Artery Disease

UNKNOWN

Computed Tomography Versus Exercise Testing in Suspected Coronary Artery Disease

NCT01393028

Angina Pectoris Chest Pain

TERMINATED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

A total of 50 patients prospectively underwent computed tomography coronary angiography (CTCA) in a multidetector CT scanner (Brilliance 64, Philips) ± 1 day before or after invasive coronary angiography (ICA). Immediately thereafter, 2 radiologists reviewed the imaging data to detect any vessel segments with morphology poorly evaluable by CTCA. A locally constant cyclical measurement was acquired in these coronary arteries in breath-hold technique during the passage of a 50ml bolus of contrast media. For analysis, time-density curves of the bolus passage were registered in the coronary artery and the aorta (internal reference), the up-slopes were determined and correlated with each other. The results were compared with the ICA findings.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Coronary Artery Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Clinically known or presumed CAD
* Age \> 50 years
* Hospitalization for invasive coronary angiography
* Sinus rhythm
* Written informed consent by the patient to participate in the study after comprehensive presentation of the facts

Exclusion Criteria

* Age \<= 50 years
* Contraindications to contrast media administration (medical history of iodine allergy, nephropathy, latent or manifest hyperthyroidism)
* Arrhythmias
* Dyspnea at rest, acute unstable angina pectoris, acute myocardial infarction
* Pregnancy
* Implanted pacemaker
* Unwillingness of patient to consent to the study

Minimum Eligible Age

51 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No