Circulating microRNAs as Biomarkers of Sepsis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-08-31

Study Completion Date

2009-06-30

Brief Summary

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MicroRNA has been demonstrated to play a crucial role in regulating cell processes. Recently, microRNA was identified to exist in human serum or plasma, and it might be related to certain diseases. Several microRNAs are involved in sepsis, such as miR-146, miR-155, and so on. But whether serum miR-146 is present in serum of septic patients remains unknown. The present study was designed to identify the existence of specific microRNAs, which might be new markers for sepsis and its prognosis.

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Detailed Description

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Conditions

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Sepsis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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sepsis group

Patients who develop sepsis in the ICU

No interventions assigned to this group

SIRS group

Patients who develop SIRS after cardiac surgery with cardiopulmonary bypass

No interventions assigned to this group

control group

normal healthy volunteers

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* patients who develop sepsis and undergo abdominal surgery
* patients who develop SIRS after cardiac surgery with cardiopulmonary bypass

Exclusion Criteria

* patients with a primary diagnosis of acute pancreatitis
* patients with cirrhosis or renal dysfunction
* patients with dyscrasia
* patients with autoimmunity diseases
* patients with severe cardiac and pulmonary diseases
* patients with hematological diseases
* patients who had organ dysfunction after cardiac surgery with cardiopulmonary bypass

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes