The Effect and Mechanism of lncRNA NBR2 Regulating Endothelial Pyroptosis by Targeting GSDMD in Sepsis
NCT ID: NCT04427371
Last Updated: 2020-06-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2020-05-22
2023-12-31
Brief Summary
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Long non-coding RNA (lncRNA), as a class of non-coding protein RNA longer than 200 kD, contributes to a variety of cell biological processes. The dysregulation of lncRNA results in the occurrence and development of tumors, diabetes, sepsis and other diseases. Therefore, we detected lncRNA and mRNA expression profile in 26 blood samples of septic patients using Arraystar LncRNA Microarray. We found lncRNA NBR2 regulates septic endothelial pyroptosis.
To assess any correlation of pyroptosis levels with relevant endothelial cell injury parameters and determine the prognostic value in septic patients. we measured the levels of pyroptosis in patients admitted to the Department of Critical Care Medicine for sepsis and investigated the correlation with related markers of endothelium injury. Furthermore, we determined the prognostic value of pyroptosis levels for the mortality of patients with sepsis.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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survivors
Improve or under treatment
the levels of pyroptosis
Blood samples were taken to detect plasma lncRNA NBR2 levels and GSDMD protein level.
nonsurvivors
all-cause 28-day mortality
the levels of pyroptosis
Blood samples were taken to detect plasma lncRNA NBR2 levels and GSDMD protein level.
Interventions
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the levels of pyroptosis
Blood samples were taken to detect plasma lncRNA NBR2 levels and GSDMD protein level.
Eligibility Criteria
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Inclusion Criteria
* The sequential organ failure score (SOFA score) increases by more than or equal to 2 points on the basis
* Sign the informed consent
Exclusion Criteria
2. pregnant
3. tumor
4. viral hepatitis or liver cirrhosis
5. chronic renal tubular nephritis, chronic renal insufficiency
6. ulcerative colitis or crohn's disease
7. active systemic lupus erythematosus (SLE)
8. acute myocardial infarction
9. acute pancreatitis
10. engaged in other clinical subjects
18 Years
80 Years
ALL
Yes
Sponsors
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Jianfeng Xie
OTHER
Responsible Party
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Jianfeng Xie
Dr.
Locations
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Zhongda Hospital, School of Medicine, Southeast University
Nanjing, Jiangsu, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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SoutheastUChina
Identifier Type: -
Identifier Source: org_study_id
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