Potential Diagnostic and Prognostic Value of microRNAs for the Patients of Sepsis-induced Myocardial Injury

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-04-30

Study Completion Date

2018-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to evaluate the potential diagnostic and prognosis value of circulating microRNAs compared with cTnI for the patients of sepsis-induced myocardial injury at the emergency department (ED) and intensive care unit (ICU).

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

MiRNAs Evaluate the Prognosis of Sepsis

NCT01207531

Sepsis

UNKNOWN

MiRNAs Evaluating Lymphocyte Proliferation and Apoptosis as Well as Prognosis of Sepsis

NCT02756559

T Lymphocyte Disorder

UNKNOWN

Defining Circulating Micro-RNA Biomarkers for the Early Diagnosis and Prognosis of Sepsis

NCT02544490

Sepsis

COMPLETED

Circulating microRNAs as Biomarkers of Sepsis

NCT00862290

Sepsis

COMPLETED

COronary Microcirculation and Troponin Elevation in Septic Shock

NCT06294730

Sepsis Myocardial Injury Coronary Microvascular Dysfunction +1 more

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Sepsis-induced Myocardial Injury

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Sepsis-induced myocardial injury group

Patients admitted to the hospital with the diagnosis of Sepsis-induced myocardial injury

No interventions assigned to this group

Blank control group

Patients admitted to the hospital without the diagnosis of Sepsis-induced myocardial injury

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Diagnosis of sepsis:SOFA score increase \>=2 at baseline level induced by infection.
2. Suspected myocardial injury,including 1 as follows at least:Low blood pressure or using vasoactive drugs; ECG changes(ST segment changes or pathological Q wave); Troponin elevation(\> 0.5 μg/L); BNP elevation(\> 4670pg/ml); Echocardiography: cardiac function decline(EF\<50%).

Exclusion Criteria

1. Skeletal muscle damage (induced by orthopedics, vascular surgery or trauma surgical disease, surgery);
2. Pregnant and lactating women;
3. Patients with mental disorders;
4. Patients are using other experimental drugs;
5. Refusal to provide informed consent

Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes