Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock
NCT ID: NCT05118646
Last Updated: 2021-11-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
62 participants
INTERVENTIONAL
2020-12-01
2021-12-30
Brief Summary
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Detailed Description
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Intervention:
1. Microcirculation-oriented resuscitation group: When the system hemodynamics meets the standard of EDGT, the microcirculation-oriented resuscitation group will evaluate the organ perfusion level and adjust the hemodynamic therapy according to the sublingual microcirculation parameters (PPV \> 68%).
2. Control group: The standard treatment group will adjust the shock management scheme through systemic hemodynamic parameters.
Primary outcome:
(1)change in SOFA score at 72h (2)30-day mortality
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
OTHER
SINGLE
Study Groups
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Microcirculation-oriented resuscitation group
The microcirculation-oriented resuscitation group will evaluate the organ perfusion level and adjust the hemodynamic therapy according to the sublingual microcirculation parameters (PPV \> 68%).
sublingual microcirculation,
Avoiding pressure artifacts, clear stable microvascular images were taken for a minimum of 20 seconds of the left, middle, and right sections of the tongue.
hemodynamic monitoring
Arterial blood lactic acid (Lac), central venous oxygen saturation (ScvO2), hematocrit (HCT) and entral venous-to-arterial carbon dioxide partial pressure difference (Pcv-aCO2) will be measured employing a bedside blood gas machine on admission and six hours following admission.
Control group
The standard treatment group will adjust the shock management scheme through systemic hemodynamic parameters.
hemodynamic monitoring
Arterial blood lactic acid (Lac), central venous oxygen saturation (ScvO2), hematocrit (HCT) and entral venous-to-arterial carbon dioxide partial pressure difference (Pcv-aCO2) will be measured employing a bedside blood gas machine on admission and six hours following admission.
Interventions
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sublingual microcirculation,
Avoiding pressure artifacts, clear stable microvascular images were taken for a minimum of 20 seconds of the left, middle, and right sections of the tongue.
hemodynamic monitoring
Arterial blood lactic acid (Lac), central venous oxygen saturation (ScvO2), hematocrit (HCT) and entral venous-to-arterial carbon dioxide partial pressure difference (Pcv-aCO2) will be measured employing a bedside blood gas machine on admission and six hours following admission.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* pregnant
* patients who were younger than 18 years old
* active bleeding
* septic shock is diagnosed for more than 4 hours
* patients are expected to be die within 24hours
18 Years
85 Years
ALL
No
Sponsors
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Xiangya Hospital of Central South University
OTHER
Responsible Party
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Principal Investigators
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lina Zhang, MD.
Role: PRINCIPAL_INVESTIGATOR
XiangYa Hospital CentralSouth University
Locations
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Xiangya Hospital of Central South University
Changsha, Hunan, China
Countries
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Central Contacts
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Facility Contacts
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Lina Zhang
Role: primary
Other Identifiers
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202006141
Identifier Type: -
Identifier Source: org_study_id