Low Dose of Midazolam is Superior to Conventional Dose for Rapid Sequence Intubation in Emergency Department (ED)

NCT ID: NCT00783731

Last Updated: 2011-07-26

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Study Classification: INTERVENTIONAL
• Study Start Date: 2008-10-31
• Study Completion Date: 2011-01-31

Brief Summary

Midazolam has been used in rapid sequence intubation for a long time, and the recommended dose is 0.1mg/kg. In some studies, however, the reduced dose has been used with the concern of hemodynamic instability. We would like to investigate that the low dose midazolam could be used rather than the standard recommended dose, and also compare it to the etomidate, recently used sedatives, with respect to the side effects and the easy performance of intubation.

Conditions

Intubation

Study Design

• Primary Study Purpose: TREATMENT

Study Groups

Low dose midazolam

Group Type: EXPERIMENTAL

Low dose midazolam

Intervention Type: DRUG

Interventions

Low dose midazolam

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• patients who need rapid sequence intubation in emergency room

Exclusion Criteria

• in hypotension(systolic blood pressure less than 90 mmHg
• severe trauma patients
• pregnant
• allergic to midazolam, etomidate

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Seoul National University Hospital

OTHER

Sponsor Role: lead

Locations

Seoul National University Bundang Hospital, Emergency room

Seongnam-si, Gyeonggi-do, South Korea

Boramae Medical Center

Seoul, , South Korea

Countries

South Korea

Other Identifiers

RSI study

Identifier Type: -

Identifier Source: org_study_id