Use of Electroconvulsive Therapy (ECT) in Chronic, Severe, Treatment Resistant Posttraumatic Stress Disorder

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-01-31

Brief Summary

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Post Traumatic Stress Disorder is a chronic debilitating illness and few treatment options have demonstrated effectiveness. The study will look at the use of electroconvulsive therapy for the treatment of Post Traumatic Stress disorder in patients who have not responded to multiple antidepressants or cognitive behavioral therapy.

Detailed Description

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Conditions

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Posttraumatic Stress Disorder

Keywords

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posttraumatic stress disorder electroconvulsive therapy medication refractoriness

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Electroconvulsive Therapy

ECT was administered using the MECTA-SR1 apparatus. The current amplitude was 800 mA, pulse width was 1.5 ms, and pulse frequency was 50 Hz. Stimulus duration was increased as required to elicit an adequate seizure, defined as at least 25 s with EEG monitoring. The ECT course was fixed, and comprised 6 treatments administered with bitemporal electrode placement at a twice-weekly frequency

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of PTSD
* Treatment resistance to 4 different antidepressants from 3 different classes
* Treatment resistance to CBT
* Severe PTSD

Exclusion Criteria

* Significant substance abuse
* Pregnancy
* History of Traumatic Brain Injury
* Unstable comorbid medical illness
* Organic brain syndrome

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Mushtaq Margoob, MD

Role: PRINCIPAL_INVESTIGATOR

Government Medical College Srinagar

Locations

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Government Hospital for Psychiatric Disease

Srinagar, Jammu and Kashmir, India

Site Status

Countries

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India

References

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Margoob MA, Ali Z, Andrade C. Efficacy of ECT in chronic, severe, antidepressant- and CBT-refractory PTSD: an open, prospective study. Brain Stimul. 2010 Jan;3(1):28-35. doi: 10.1016/j.brs.2009.04.005. Epub 2009 May 27.

Reference Type DERIVED

PMID: 20633428 (View on PubMed)

Other Identifiers

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GMCPTSD_ECT2005

Identifier Type: -

Identifier Source: org_study_id