Treatment of Post Traumatic Stress Disorder in Patients With Other Mental Illnesses

NCT ID: NCT00053690

Last Updated: 2013-09-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

88 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-01-31

Study Completion Date

2004-12-31

Brief Summary

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The purpose of this study is to develop an effective treatment for people with Post Traumatic Stress Disorder (PTSD) along with other mental illnesses.

Detailed Description

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Despite the progress in treating PTSD in the general population and the elevated prevalence of PTSD in people with severe mental illness (SMI), there are no empirically validated treatments designed for patients with comorbid PTSD. The cognitive behavioral treatment provided in this study may improve knowledge of PTSD, decrease distorted beliefs, reduce PTSD symptoms, and improve quality of life.

Participants are randomly assigned to receive either a cognitive behavioral treatment plus standard care for SMI or standard care alone. The cognitive behavioral treatment incorporates several common features, including psychoeducation, relaxation training, and cognitive restructuring. Standard care for SMI includes medication, case management, and psychosocial treatment. PTSD, psychiatric symptoms, health, quality of life, and substance abuse outcomes are measured. Participants' knowledge of PTSD and beliefs about the world are also measured. Participants are assessed at baseline, post-treatment (16 weeks), and at 3- and 6-month follow-ups.

For information on a related study, please follow this link:

http://clinicaltrials.gov/show/NCT00494650

Conditions

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Stress Disorders, Post-Traumatic

Keywords

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Comorbidity Schizophrenia Bipolar Disorder Depression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Cognitive Behavior Treatment

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Post Traumatic Stress Disorder
* New Hampshire definition of SMI plus DSM-IV Axis I diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, or major depression
* Case management services and contact with a case manager at least twice a week

Exclusion Criteria

* Alcohol or drug dependence
* Hospitalization or suicide attempt in the past 2 months
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Mental Health (NIMH)

NIH

Sponsor Role collaborator

Dartmouth-Hitchcock Medical Center

OTHER

Sponsor Role lead

Principal Investigators

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Kim Mueser, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Dartmouth-Hitchcock Medical Center

Stanley Rosenberg, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Dartmouth-Hitchcock Medical Center

Locations

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Community Mental Health Centers in NH

Claremont, New Hampshire, United States

Site Status

Countries

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United States

References

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Mueser KT, McGurk SR, Xie H, Bolton EE, Jankowski MK, Lu W, Rosenberg SD, Wolfe R. Neuropsychological predictors of response to cognitive behavioral therapy for posttraumatic stress disorder in persons with severe mental illness. Psychiatry Res. 2018 Jan;259:110-116. doi: 10.1016/j.psychres.2017.10.016. Epub 2017 Oct 6.

Reference Type DERIVED
PMID: 29040946 (View on PubMed)

Other Identifiers

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R01MH064662-01

Identifier Type: NIH

Identifier Source: secondary_id

View Link

DSIR AT-SP

Identifier Type: -

Identifier Source: secondary_id

R01MH064662-01

Identifier Type: NIH

Identifier Source: org_study_id

View Link