Ghrelin Regulation and Structure: Effect of Diet Composition on Ghrelin
NCT ID: NCT00694512
Last Updated: 2012-05-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
51 participants
INTERVENTIONAL
2008-02-29
2011-03-31
Brief Summary
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Detailed Description
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PWS subjects will have one admission after eating a standardized diet prepared by caregivers for 2 weeks.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
QUADRUPLE
Study Groups
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1
low fat diet for two weeks.
Low fat diet
20% fat diet
2
High fat diet for two weeks followed by blood sampling.
High fat diet
40% fat diet
3
Medium Chain Triglyceride diet
MCT diet
Medium chain triglyceride diet
Interventions
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Low fat diet
20% fat diet
High fat diet
40% fat diet
MCT diet
Medium chain triglyceride diet
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Weight stable for at least 3 months.
* At lifetime maximal body weight.
Exclusion Criteria
* Smokers.
* Alcohol consumption \> 2 drinks per day.
* Exercise \> 30 minutes 3 times a week.
* Prescription drug use (except birth control pills, vitamins, or minerals).
* Type 2 diabetes.
* Heart disease, cancer, malabsorptive states, or chronic infections that would affect body weight.
* Weight \> 300 lbs (exceeds the weight limit of the DEXA machine).
* Hemoglobin \< 12.0 g/dL for women, \< 13.5 g/dL for men
18 Years
ALL
Yes
Sponsors
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Oregon Health and Science University
OTHER
Responsible Party
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OHSU - Center for the Study of Weight Regulation
Principal Investigators
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Jonathan Q. Purnell, M.D.
Role: PRINCIPAL_INVESTIGATOR
Oregon Health and Science University
Locations
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Oregon Health & Science University
Portland, Oregon, United States
Countries
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Other Identifiers
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OCTRI 1048
Identifier Type: OTHER
Identifier Source: secondary_id
eIRB #3224
Identifier Type: OTHER
Identifier Source: secondary_id
eIRB 3224
Identifier Type: -
Identifier Source: org_study_id
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